10.25384/SAGE.C.5120167.V1
Maaike Schilperoort
Maaike
Schilperoort
Rosa van den Berg
Rosa
van den Berg
Claudia P. Coomans
Claudia P.
Coomans
Padmini P. S. J. Khedoe
Padmini P. S. J.
Khedoe
Ashna Ramkisoensing
Ashna
Ramkisoensing
Sanne Boekestijn
Sanne
Boekestijn
Yanan Wang
Yanan
Wang
Jimmy F. P. Berbée
Jimmy F. P.
Berbée
Johanna H. Meijer
Johanna H.
Meijer
Nienke R. Biermasz
Nienke R.
Biermasz
Patrick C. N. Rensen
Patrick C. N.
Rensen
Sander Kooijman
Sander
Kooijman
Continuous Light Does Not Affect Atherosclerosis in APOE*3-Leiden.CETP Mice
<div><p>Artificial light exposure is associated with dyslipidemia in humans, which is a major risk factor for the development of atherosclerotic cardiovascular disease. However, it remains unclear whether artificial light at night can exacerbate atherosclerosis. In this study, we exposed female APOE*3-Leiden.CETP mice, a well-established model for human-like lipid metabolism and atherosclerosis, to either a regular light-dark cycle or to constant bright light for 14 weeks. Mice exposed to constant light demonstrated a minor reduction in food intake, without any effect on body weight, body composition, or the weight of metabolic organs. Constant light increased the plasma levels of proatherogenic non–high-density lipoprotein (HDL) cholesterol but did not increase the size or severity of atherosclerotic lesions in the aortic root. Mice exposed to constant light did show lower immune cell counts, which could explain the absence of an effect of atherosclerosis despite increased non–HDL cholesterol levels. Behavioral analysis demonstrated variability in the response of mice to the light intervention. Constant light completely blunted behavioral rhythms in some mice, while others extended their behavioral period. However, rhythm strength was not an important determinant of atherosclerosis. Altogether, these results demonstrate that constant bright light does not affect atherosclerosis in APOE*3-Leiden.CETP mice. Whether artificial light exposure contributes to cardiovascular disease risk in humans remains to be investigated.</p></div>
Endocrinology
Biological Sciences not elsewhere classified
Neuroscience
SAGE Journals
2020
2020-09-13
2020-09-13
Collection
10.25384/SAGE.c.5120167
CC BY 4.0