10.2312/VCBM/VCBM08/045-051
Bene, Petr
Medek, Petr
Sochor, Jiri
Computation of More Channels in Protein Molecules
The Eurographics Association
2008
Categories and Subject Descriptors (according to ACM CCS): I.3.5 [Computer Graphics]: Geometric algorithms, languages, and systems
eng
2070-5786
978-3-905674-13-2
http://diglib.eg.org/EG/DL/WS/VCBM/VCBM08/045-051.pdf
7 pages
Eurographics Workshop on Visual Computing for Biomedicine
In the process of designing drugs it is crucial to perform various analyses of cavities and channels in protein molecules. Chemists also require that more than one ideal channel be computed in a static protein molecule. Three basic approaches for computation of more than a single channel were introduced in recent publications. However, these approaches have several disadvantages. In this paper we propose a new adaptive method for computation of more channels. This new method is piloted on a real data and results are compared with channels identified by chemists as relevant. The comparison indicates that this method is a significant improvement over previous methods, as the method computes less number of similar and biochemically insignificant channels.