10.17863/CAM.18638
Flannick, Jason
Fuchsberger, Christian
Mahajan, Anubha
Teslovich, Tanya M
Agarwala, Vineeta
Gaulton, Kyle J
0000-0003-1318-7161
Caulkins, Lizz
Koesterer, Ryan
Ma, Clement
Moutsianas, Loukas
McCarthy, Davis J
Rivas, Manuel A
Perry, John RB
Sim, Xueling
Blackwell, Thomas W
Robertson, Neil R
Rayner, N William
Cingolani, Pablo
Locke, Adam E
0000-0001-6227-198X
Tajes, Juan Fernandez
Highland, Heather M
Dupuis, Josee
Chines, Peter S
Lindgren, Cecilia M
Hartl, Christopher
Jackson, Anne U
Chen, Han
Huyghe, Jeroen R
van de Bunt, Martijn
0000-0002-6744-6125
Pearson, Richard D
Kumar, Ashish
Müller-Nurasyid, Martina
0000-0002-7898-2353
Grarup, Niels
0000-0001-5526-1070
Stringham, Heather M
0000-0002-2991-6392
Gamazon, Eric R
0000-0003-4204-8734
Lee, Jaehoon
Chen, Yuhui
Scott, Robert A
Below, Jennifer E
Chen, Peng
Huang, Jinyan
Go, Min Jin
Stitzel, Michael L
Pasko, Dorota
Parker, Stephen CJ
Varga, Tibor V
0000-0002-2383-699X
Green, Todd
Beer, Nicola L
0000-0002-4964-7150
Day-Williams, Aaron G
Ferreira, Teresa
Fingerlin, Tasha
Horikoshi, Momoko
Hu, Cheng
Huh, Iksoo
Ikram, Mohammad Kamran
Kim, Bong-Jo
Kim, Yongkang
Kim, Young Jin
Kwon, Min-Seok
Lee, Juyoung
Lee, Selyeong
Lin, Keng-Han
Maxwell, Taylor J
Nagai, Yoshihiko
Wang, Xu
Welch, Ryan P
0000-0001-6378-1295
Yoon, Joon
0000-0002-9509-119X
Zhang, Weihua
Barzilai, Nir
Voight, Benjamin F
0000-0002-6205-9994
Han, Bok-Ghee
Jenkinson, Christopher P
Kuulasmaa, Teemu
Kuusisto, Johanna
Manning, Alisa
Ng, Maggie CY
Palmer, Nicholette D
Balkau, Beverley
Stančáková, Alena
Abboud, Hanna E
Boeing, Heiner
Giedraitis, Vilmantas
0000-0003-3423-2021
Prabhakaran, Dorairaj
Gottesman, Omri
Scott, James
Carey, Jason
Kwan, Phoenix
Grant, George
Smith, Joshua D
Neale, Benjamin M
0000-0003-1513-6077
Purcell, Shaun
Butterworth, Adam S
Howson, Joanna MM
Lee, Heung Man
Lu, Yingchang
Kwak, Soo-Heon
Zhao, Wei
Danesh, John
Lam, Vincent KL
Park, Kyong Soo
0000-0003-3597-342X
Saleheen, Danish
So, Wing Yee
Tam, Claudia HT
Afzal, Uzma
Aguilar, David
Arya, Rector
Aung, Tin
Chan, Edmund
Navarro, Carmen
Cheng, Ching-Yu
Palli, Domenico
0000-0002-5558-2437
Correa, Adolfo
Curran, Joanne E
Rybin, Dennis
Farook, Vidya S
Fowler, Sharon P
Freedman, Barry I
Griswold, Michael
Hale, Daniel Esten
Hicks, Pamela J
Khor, Chiea-Chuen
0000-0002-1128-4729
Kumar, Satish
0000-0002-1969-4431
Lehne, Benjamin
Thuillier, Dorothée
Lim, Wei Yen
Liu, Jianjun
Loh, Marie
Musani, Solomon K
Puppala, Sobha
Scott, William R
Yengo, Loïc
Tan, Sian-Tsung
Taylor, Herman A
Thameem, Farook
Wilson, Gregory
Wong, Tien Yin
Njølstad, Pål Rasmus
Levy, Jonathan C
Mangino, Massimo
0000-0002-2167-7470
Bonnycastle, Lori L
Schwarzmayr, Thomas
Fadista, João
Surdulescu, Gabriela L
Herder, Christian
0000-0002-2050-093X
Groves, Christopher J
Wieland, Thomas
Bork-Jensen, Jette
Brandslund, Ivan
Christensen, Cramer
Koistinen, Heikki A
0000-0001-7870-070X
Doney, Alex SF
Kinnunen, Leena
Esko, Tõnu
Farmer, Andrew J
Hakaste, Liisa
Hodgkiss, Dylan
Kravic, Jasmina
Lyssenko, Valeri
Hollensted, Mette
Jørgensen, Marit E
Jørgensen, Torben
Ladenvall, Claes
Justesen, Johanne Marie
0000-0002-0484-8522
Käräjämäki, Annemari
Kriebel, Jennifer
0000-0003-4270-018X
Rathmann, Wolfgang
Lannfelt, Lars
Lauritzen, Torsten
Narisu, Narisu
Linneberg, Allan
Melander, Olle
Milani, Lili
0000-0002-5323-3102
Neville, Matt
Orho-Melander, Marju
Qi, Lu
Qi, Qibin
Roden, Michael
Rolandsson, Olov
Swift, Amy
Rosengren, Anders H
Stirrups, Kathleen
Wood, Andrew R
Mihailov, Evelin
Blancher, Christine
Carneiro, Mauricio O
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Fennell, Timothy
DePristo, Mark
de Angelis, Martin Hrabé
Deloukas, Panos
0000-0001-9251-070X
Gjesing, Anette P
Jun, Goo
Nilsson, Peter
Murphy, Jacquelyn
Onofrio, Robert
Thorand, Barbara
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Huth, Cornelia
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0000-0002-8306-6202
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Bharadwaj, Dwaipayan
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0000-0002-7511-5684
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0000-0002-1227-803X
Pollin, Toni I
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Tandon, Nikhil
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0000-0003-2972-0784
Barroso, Inês
0000-0001-5800-4520
Teo, Yik Ying
Zeggini, Eleftheria
0000-0003-4238-659X
Loos, Ruth JF
0000-0002-8532-5087
Small, Kerrin S
0000-0003-4566-0005
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DeFronzo, Ralph A
Grallert, Harald
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Metspalu, Andres
Wareham, Nicholas J
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0000-0003-0333-5685
Illig, Thomas
Franks, Paul W
Buck, Gemma
Trakalo, Joseph
Buck, David
Prokopenko, Inga
0000-0003-1624-7457
Mägi, Reedik
Lind, Lars
Farjoun, Yossi
Owen, Katharine R
Gloyn, Anna L
0000-0003-1205-1844
Strauch, Konstantin
Tuomi, Tiinamaija
Kooner, Jaspal Singh
Lee, Jong-Young
0000-0002-0092-9958
Park, Taesung
Donnelly, Peter
Morris, Andrew D
Hattersley, Andrew T
Bowden, Donald W
Collins, Francis S
Atzmon, Gil
Chambers, John C
Spector, Timothy D
Laakso, Markku
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Blangero, John
Duggirala, Ravindranath
Tai, E Shyong
McVean, Gilean
Hanis, Craig L
Wilson, James G
Seielstad, Mark
0000-0001-5783-1401
Frayling, Timothy M
Meigs, James B
Cox, Nancy J
Sladek, Rob
Lander, Eric S
Gabriel, Stacey
Mohlke, Karen L
0000-0001-6721-153X
Meitinger, Thomas
Groop, Leif
0000-0002-0187-3263
Abecasis, Goncalo
Scott, Laura J
Morris, Andrew P
Kang, Hyun Min
Altshuler, David
Burtt, Noël P
Florez, Jose C
Boehnke, Michael
McCarthy, Mark I
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.
Springer Science and Business Media LLC
2017
Diabetes Mellitus, Type 2
Genetic Variation
Humans
White People
Apollo - University of Cambridge Repository
University of Cambridge
013meh722
2018-02-05
2018-02-05
2017-12-19
eng
Article
https://www.repository.cam.ac.uk/handle/1810/271644
10.1038/sdata.2017.179
Attribution 4.0 International
Attribution 4.0 International
http://creativecommons.org/licenses/by/4.0/
http://creativecommons.org/licenses/by/4.0/
open.access
To investigate the genetic basis of type 2 diabetes (T2D) to high resolution, the GoT2D and T2D-GENES consortia catalogued variation from whole-genome sequencing of 2,657 European individuals and exome sequencing of 12,940 individuals of multiple ancestries. Over 27M SNPs, indels, and structural variants were identified, including 99% of low-frequency (minor allele frequency [MAF] 0.1-5%) non-coding variants in the whole-genome sequenced individuals and 99.7% of low-frequency coding variants in the whole-exome sequenced individuals. Each variant was tested for association with T2D in the sequenced individuals, and, to increase power, most were tested in larger numbers of individuals (>80% of low-frequency coding variants in ~82 K Europeans via the exome chip, and ~90% of low-frequency non-coding variants in ~44 K Europeans via genotype imputation). The variants, genotypes, and association statistics from these analyses provide the largest reference to date of human genetic information relevant to T2D, for use in activities such as T2D-focused genotype imputation, functional characterization of variants or genes, and other novel analyses to detect associations between sequence variation and T2D.
Medical Research Council
MC_UU_12015/1
Department of Health (via National Institute for Health Research (NIHR))
NF-SI-0512-10135
Medical Research Council
MC_UU_12015/2
Medical Research Council
MR/L003120/1
National Institutes of Health (NIH) (via University of Oxford)
NIH R13579/CN038
British Heart Foundation