10.17639/NOTT.6421
Georgiou, Marios
An in vivo systematic genetic analysis of tumour progression in Drosophila - RNAi line: 39446
University of Nottingham
2019
Metastasis
Cancer -- Molecular aspects
Cancer -- Genetic aspects
Neoplasm Metastasis
Molecular Biology
Neoplasms -- genetics
Drosophila, cancer, invasion, metastasis, screen, RNAi, lgl, tumour suppressor, invasion suppressor
Biological Sciences::Zoology::Cell zoology
Biological Sciences::Biology::Cell biology
Biological Sciences::Genetics::Medical & veterinary genetics
Q Science::QL Zoology::QL360 Invertebrates
Q Science::QH Natural history. Biology::QH426 Genetics
Q Science::QH Natural history. Biology::QH201 Microscopy
R Medicine::RC Internal medicine::RC 254 Neoplasms. Tumors. Oncology (including Cancer)
University Of Nottingham
University Of Nottingham
Canales Coutino, Brenda
Cornhill, Zoe E.
Couto, Africa
Mack, Natalie A.
Rusu, Alexandra D.
Nagarajan, Usha
Fan, Yuen Ngan
Hadjicharalambous, Marina R.
Lourdusamy, Anbarasu
Castellanos Uribe, Marcos
May, Sean T.
Rahman, Ruman
2019-05-10
2019-05-01
en
Other
https://rdmc.nottingham.ac.uk/handle/internal/6428
http://flycancerscreen.nottingham.ac.uk
http://flybase.org/reports/FBgn0085409
This data set forms part of the larger 'Fly Cancer Screen' data set, which consists of over 700 image sets
Metastasis is the leading cause of death for cancer patients. Consequently it is imperative that we improve our understanding of the molecular mechanisms that underlie progression of tumour growth towards malignancy. Advances in genome characterisation technologies have been very successful in identifying commonly mutated or misregulated genes in a variety of human cancers. A major challenge however is the translation of these findings to new biological insight due to the difficulty in evaluating whether these candidate genes drive tumour progression. Using the genetic amenability of Drosophila melanogaster we generated tumours with specific genotypes in the living animal and carried out a detailed systematic loss-of-function analysis to identify numerous conserved genes that enhance or suppress epithelial tumour progression. This enabled the discovery of functional cooperative regulators of invasion and the establishment of a network of conserved ‘invasion suppressors’. RNAi line: 39446 (III) Source: VDRC Name: CG34380 (2) Full name: smoke alarm Also known as: smal Annotation symbol: CG34380 FlyBase ID: FBgn0085409 File naming convention: File names typically contain representations of date (DDMMYY), RNAi Line, Animal Number and, in some cases, window (to accommodate larger samples that require multiple image stacks)