10.17632/N66N5PJ4F6.1
Ramirez, Sydney
0000-0002-7166-5195
Antigen-specific adaptive immunity to SARS-CoV-2 in acute COVID-19 and associations with age and disease severity. Moderbacher et al.
Mendeley
2020
Immunology
Antibody
T Cell
Adaptive Immunity
Severe Acute Respiratory Syndrome Coronavirus 2
COVID-19
Rydyznski Moderbacher, Carolyn
Dan, Jennifer
Grifoni, Alba
Hastie, Kathryn
Weiskopf, Daniela
Belanger, Simon
Abbott, Robert
Kim, Christina
Choi, Jinyong
Kato, Yu
Crotty, Eleanor
Kim, Cheryl
Rawlings, Stephen
Mateus, Jose
Tse, Long Ping Victor
Frazier, April
Baric, Ralph
Peters, Bjoern
Greenbaum, Jason
Ollmann Saphire, Erica
Smith, Davey
Sette, Alessandro
Crotty, Shane
2020-09-11
Dataset
Creative Commons Attribution 4.0 International
We conducted an analysis of SARS-CoV-2 specific adaptive immune responses during acute COVID-19 in comparison with convalescent COVID-19 and unexposed, healthy controls and identified that coordination between SARS-CoV-2-specific CD4 T cells and CD8 T cells limits disease severity in COVID-19. Aged individuals more often exhibited uncoordinated adaptive responses, potentially tied to scarcity of naive T cells, highlighting immunologic risk factors linked to COVID-19 disease severity. The data available here include a simplified parameters sheet with experimental and donor information for the healthy unexposed, acute COVID-19, and convalescent COVID-19 donor samples included in this study. Additional information about the fields, field names, calculations, and patient cohorts are all provided in the published paper.
10.17632/n66n5pj4f6