{
"id": "https://doi.org/10.7490/f1000research.1110050.1",
"doi": "10.7490/F1000RESEARCH.1110050.1",
"url": "http://f1000research.com/posters/4-331",
"types": {
"ris": "GEN",
"bibtex": "misc",
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"creators": [
{
"name": "Schmidt, Esther",
"nameType": "Personal",
"givenName": "Esther",
"familyName": "Schmidt",
"affiliation": []
},
{
"name": "Pelz, Oliver",
"nameType": "Personal",
"givenName": "Oliver",
"familyName": "Pelz",
"affiliation": []
},
{
"name": "Buhlmann, Svetlana",
"nameType": "Personal",
"givenName": "Svetlana",
"familyName": "Buhlmann",
"affiliation": []
},
{
"name": "Fleckenstein, Hannah",
"nameType": "Personal",
"givenName": "Hannah",
"familyName": "Fleckenstein",
"affiliation": []
},
{
"name": "Mehl, Johanna",
"nameType": "Personal",
"givenName": "Johanna",
"familyName": "Mehl",
"affiliation": []
},
{
"name": "Boutros, Michael",
"nameType": "Personal",
"givenName": "Michael",
"familyName": "Boutros",
"affiliation": []
}
],
"titles": [
{
"title": "GenomeRNAi: A phenotype database for large-scale RNAi screens"
}
],
"publisher": {
"name": "F1000Research"
},
"container": {},
"subjects": [],
"contributors": [],
"dates": [
{
"date": "2015",
"dateType": "Issued"
}
],
"publicationYear": 2015,
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"descriptions": [
{
"description": "RNA interference (RNAi) represents a popular approach for the systematic perturbation of gene expression. Large-scale screening experiments can be performed, employing a wide variety of biological assays, resulting in the observation of loss-of-function phenotypes across many fields in biology. These phenotypes constitute a rich source of functional gene annotation.
The GenomeRNAi database is a repository for RNAi phenotype and reagent data, aiming to provide a platform for data mining and comparisons. Data is extracted from the literature by manual curation, or directly submitted by data producers, followed by curatorial review according to structured annotation guidelines. Currently, the database contains 217 experiments in human, and 201 experiments in Drosophila, totaling to more than 1,2 million individual gene-phenotype associations. It also holds information on more than 400,000 RNAi reagents, along with quality assessment data like efficiency and specificity.
GenomeRNAi (www.genomernai.org) provides functionalities for searching (by gene, reagent, or phenotype), browsing and downloading experiments. A DAS server allows visualization of reagents and phenotypes in their genomic context. The website features a “frequent hitter” page; further a functionality for the overlay of genes sharing the same phenotype onto known gene networks provided by the String database (www.string-db.org); as well as a beta version of a screen comparison tool, implemented as a heat map-like overview of genes and their phenotypes in different screens. GenomeRNAi data are well integrated with external resources, providing e.g. mutual links with FlyBase, GeneCards and UniProt. GenomeRNAi functional data have also been incorporated into the FlyMine tool.",
"descriptionType": "Other"
}
],
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