{
"id": "https://doi.org/10.6084/m9.figshare.9963101.v1",
"doi": "10.6084/M9.FIGSHARE.9963101.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/VHPKQHR_peptide_modified_magnetic_mesoporous_nanoparticles_for_MRI_detection_of_atherosclerosis_lesions/9963101/1",
"types": {
"ris": "RPRT",
"bibtex": "article",
"citeproc": "article-journal",
"schemaOrg": "ScholarlyArticle",
"resourceType": "Journal contribution",
"resourceTypeGeneral": "Text"
},
"creators": [
{
"name": "Xu, Wan",
"givenName": "Wan",
"familyName": "Xu"
},
{
"name": "Zhang, Shuihua",
"givenName": "Shuihua",
"familyName": "Zhang"
},
{
"name": "Zhou, Quan",
"givenName": "Quan",
"familyName": "Zhou"
},
{
"name": "Chen, Wenli",
"givenName": "Wenli",
"familyName": "Chen"
}
],
"titles": [
{
"title": "VHPKQHR peptide modified magnetic mesoporous nanoparticles for MRI detection of atherosclerosis lesions"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Space Science"
},
{
"subject": "Medicine"
},
{
"subject": "Cell Biology"
},
{
"subject": "Pharmacology"
},
{
"subject": "Biotechnology"
},
{
"subject": "Chemical Sciences not elsewhere classified"
},
{
"subject": "Biological Sciences not elsewhere classified"
},
{
"subject": "Cancer"
}
],
"contributors": [],
"dates": [
{
"date": "2019-10-10",
"dateType": "Created"
},
{
"date": "2024-02-05",
"dateType": "Updated"
},
{
"date": "2019",
"dateType": "Issued"
}
],
"publicationYear": 2019,
"identifiers": [],
"sizes": [
"1282378 Bytes"
],
"formats": [],
"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Mortality attributable to atherosclerosis can be reduced significantly with timely diagnosis and treatment. It is meaningful to find a proper way to diagnose and prevent the progression of atherosclerosis. Vascular cell adhesion molecule-1 (VCAM-1) expressed by endothelial cells is a prominent marker of atherosclerotic plaques. There are a number of researches on VCAM-1 based probes for targeted imaging, but rarely on a system with both targeting and drug delivery. Here, we report a novel magnetic mesoporous silicon nanoparticle that is capable of drug delivery and targeting at atherosclerosis plaque. The nanoparticles were constructed using incorporated FITC (fluorescein isothiocyanate) and VHPKQHR peptide into Fe3O4@SiO2 (FITC-VHP-Fe3O4@SiO2). The FITC-VHP-Fe3O4@SiO2 nanoparticles showed great morphological characteristics, superior targeting ability, low toxicity and good biocompatibility in vitro and in vivo. The in vivo experiments showed that FITC-VHP-Fe3O4@SiO2 is a superior contrast agent of magnetic resonance imaging (MRI) for diagnosis of atherosclerosis plaques.",
"descriptionType": "Abstract"
}
],
"geoLocations": [],
"fundingReferences": [],
"relatedIdentifiers": [
{
"relationType": "IsIdenticalTo",
"relatedIdentifier": "10.6084/m9.figshare.9963101",
"relatedIdentifierType": "DOI"
},
{
"relationType": "IsSupplementTo",
"relatedIdentifier": "10.1080/21691401.2019.1626411",
"relatedIdentifierType": "DOI"
}
],
"relatedItems": [],
"schemaVersion": "http://datacite.org/schema/kernel-4",
"providerId": "otjm",
"clientId": "figshare.ars",
"agency": "datacite",
"state": "findable"
}