{
"id": "https://doi.org/10.6084/m9.figshare.8306102.v1",
"doi": "10.6084/M9.FIGSHARE.8306102.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/Hsa_Circ_0001206_is_downregulated_and_inhibits_cell_proliferation_migration_and_invasion_in_prostate_cancer/8306102/1",
"types": {
"ris": "RPRT",
"bibtex": "article",
"citeproc": "article-journal",
"schemaOrg": "ScholarlyArticle",
"resourceType": "Journal contribution",
"resourceTypeGeneral": "Text"
},
"creators": [
{
"name": "Song, Zhenyu",
"givenName": "Zhenyu",
"familyName": "Song"
},
{
"name": "Zhuo, Zhiyuan",
"givenName": "Zhiyuan",
"familyName": "Zhuo"
},
{
"name": "Ma, Zhe",
"givenName": "Zhe",
"familyName": "Ma"
},
{
"name": "Hou, Chuansheng",
"givenName": "Chuansheng",
"familyName": "Hou"
},
{
"name": "Chen, Gang",
"givenName": "Gang",
"familyName": "Chen"
},
{
"name": "Xu, Guoxiong",
"givenName": "Guoxiong",
"familyName": "Xu"
}
],
"titles": [
{
"title": "Hsa_Circ_0001206 is downregulated and inhibits cell proliferation, migration and invasion in prostate cancer"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biophysics"
},
{
"subject": "Biochemistry"
},
{
"subject": "Physical Sciences not elsewhere classified"
},
{
"subject": "Medicine"
},
{
"subject": "Cell Biology"
},
{
"subject": "Genetics"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Molecular Biology"
},
{
"subject": "Pharmacology"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Biological Sciences not elsewhere classified"
},
{
"subject": "Infectious Diseases"
},
{
"subject": "FOS: Health sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
}
],
"contributors": [],
"dates": [
{
"date": "2019-06-21",
"dateType": "Created"
},
{
"date": "2024-02-26",
"dateType": "Updated"
},
{
"date": "2019",
"dateType": "Issued"
}
],
"publicationYear": 2019,
"identifiers": [],
"sizes": [
"21051 Bytes"
],
"formats": [],
"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Our study is to explore the expression profiles and potential functions of circRNAs in prostate cancer (PCa). A total of 95 circRNAs and 830 mRNAs were screened to be significantly differentially expressed in PCa tissues by microarrays. Co-expression and competitive endogenous RNA (ceRNA) network were constructed to reveal the potential regulatory mechanisms of circRNAs. Three circRNAs, hsa_circ_0001206, hsa_circ_0001633, and hsa_circ_0009061 were validated to be down-regulated in PCa by quantitative real-time PCR (qRT-PCR) and hsa_circ_0001206 as well as hsa_circ_0009061 was significantly associated with clinical features of PCa patients. Meanwhile, Receiver Operating Characteristic (ROC) curves showed their good diagnostic value as biomarkers for PCa. The down-regulation of hsa_circ_001206 was partly because of the regulation of DExH-Box Helicase 9 (DHX9). Moreover, overexpression of hsa_circ_0001206 inhibited PCa cell proliferation, migration, and invasion in vitro and prevented tumor growth in vivo. Dual-luciferase reporter assays showed hsa_circ_0001206 could directly bind to miR-1285-5p. The expression of Smad4, a well-known suppressive gene in PCa, can be increased by overexpression of hsa_circ_0001206 and this effect could be partly reversed by co-transfection of miR-1285-5p mimic. The study revealed expression profiles and potential functions of circRNAs and demonstrated hsa_circ_0001206 played a suppressive role in the pathogenesis of PCa.",
"descriptionType": "Abstract"
}
],
"geoLocations": [],
"fundingReferences": [],
"relatedIdentifiers": [
{
"relationType": "IsIdenticalTo",
"relatedIdentifier": "10.6084/m9.figshare.8306102",
"relatedIdentifierType": "DOI"
},
{
"relationType": "IsSupplementTo",
"relatedIdentifier": "10.1080/21691401.2019.1626866",
"relatedIdentifierType": "DOI"
}
],
"relatedItems": [],
"schemaVersion": "http://datacite.org/schema/kernel-4",
"providerId": "otjm",
"clientId": "figshare.ars",
"agency": "datacite",
"state": "findable"
}