{
"id": "https://doi.org/10.6084/m9.figshare.7792490.v1",
"doi": "10.6084/M9.FIGSHARE.7792490.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/A_study_of_the_association_between_the_sFlt-1_PIGF_ratio_and_preeclampsia_in_Xinjiang_Uygur_Autonomous_Region_of_China/7792490/1",
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"creators": [
{
"name": "Ding, Guifeng",
"givenName": "Guifeng",
"familyName": "Ding"
},
{
"name": "Liping, Liu",
"givenName": "Liu",
"familyName": "Liping"
},
{
"name": "Moli, Duan",
"givenName": "Duan",
"familyName": "Moli"
},
{
"name": "Wuliyeti, Aibibula",
"givenName": "Aibibula",
"familyName": "Wuliyeti"
},
{
"name": "Shaohe, Zhou",
"givenName": "Zhou",
"familyName": "Shaohe"
},
{
"name": "Huijuan, Wang",
"givenName": "Wang",
"familyName": "Huijuan"
},
{
"name": "Chen, Peng",
"givenName": "Peng",
"familyName": "Chen"
},
{
"name": "Chen, Chao",
"givenName": "Chao",
"familyName": "Chen"
},
{
"name": "Guiqin, Bai",
"givenName": "Bai",
"familyName": "Guiqin"
}
],
"titles": [
{
"title": "A study of the association between the sFlt-1/PIGF ratio and preeclampsia in Xinjiang Uygur Autonomous Region of China"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biochemistry"
},
{
"subject": "Medicine"
},
{
"subject": "Cell Biology"
},
{
"subject": "Genetics"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Mathematical Sciences not elsewhere classified"
}
],
"contributors": [],
"dates": [
{
"date": "2019-03-01",
"dateType": "Created"
},
{
"date": "2024-02-28",
"dateType": "Updated"
},
{
"date": "2019",
"dateType": "Issued"
}
],
"publicationYear": 2019,
"identifiers": [],
"sizes": [
"16324 Bytes"
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "It was previously reported that the ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) can predict the clinical onset of preeclampsia. This study seeks to validate the association between ratios of sFlt-1/PlGF with preeclampsia and to identify the contribution of ethnicity across diverse populations of the Xinjiang Uygur Autonomous Region. Pregnant women were classified into those with preeclampsia (n = 136) and healthy controls (n = 350). Serum levels of sFlt-1 and PlGF were quantified using a Roche serum instrument in both patients and controls. Compared to healthy controls, women with preeclampsia had significantly higher levels of sFlt-1 (7303.81 pg/ml vs. 2508.69 pg/ml, p < .001) and ratios of sFlt-1/PlGF (241.68 vs. 14.29, p < .001), whereas levels of PIGF were decreased (241.68 vs. 14.29, p < .001). These three values varied greatly across nationalities, and non-Han Chinese subjects (including Uygur, Kazak, Hui) were more likely to experience severe preeclampsia than Han Chinese subjects. This is the first study to demonstrate that the ratio of sFlt-1/PlGF can both predict and serve as a diagnostic factor for preeclampsia in pregnant women from different populations within the Xinjiang region of China.",
"descriptionType": "Abstract"
}
],
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"relatedIdentifier": "10.1080/21691401.2018.1491480",
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