{
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"url": "https://tandf.figshare.com/articles/dataset/Booster_vaccination_is_required_to_elicit_and_maintain_COVID-19_vaccine-induced_immunity_in_SIV-infected_macaques/21334010",
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"creators": [
{
"name": "Li, Pingchao",
"givenName": "Pingchao",
"familyName": "Li"
},
{
"name": "Wang, Qian",
"givenName": "Qian",
"familyName": "Wang"
},
{
"name": "He, Yizi",
"givenName": "Yizi",
"familyName": "He"
},
{
"name": "Yang, Chenchen",
"givenName": "Chenchen",
"familyName": "Yang"
},
{
"name": "Zhang, Zhengyuan",
"givenName": "Zhengyuan",
"familyName": "Zhang"
},
{
"name": "Liu, Zijian",
"givenName": "Zijian",
"familyName": "Liu"
},
{
"name": "Liu, Bo",
"givenName": "Bo",
"familyName": "Liu"
},
{
"name": "Yin, Li",
"givenName": "Li",
"familyName": "Yin"
},
{
"name": "Cui, Yilan",
"givenName": "Yilan",
"familyName": "Cui"
},
{
"name": "Hu, Peiyu",
"givenName": "Peiyu",
"familyName": "Hu"
},
{
"name": "Liu, Yichu",
"givenName": "Yichu",
"familyName": "Liu"
},
{
"name": "Zheng, Pingqian",
"givenName": "Pingqian",
"familyName": "Zheng"
},
{
"name": "Wang, Wei",
"givenName": "Wei",
"familyName": "Wang"
},
{
"name": "Qu, Linbing",
"givenName": "Linbing",
"familyName": "Qu"
},
{
"name": "Sun, Caijun",
"givenName": "Caijun",
"familyName": "Sun"
},
{
"name": "Guan, Suhua",
"givenName": "Suhua",
"familyName": "Guan"
},
{
"name": "Feng, Liqiang",
"givenName": "Liqiang",
"familyName": "Feng"
},
{
"name": "Chen, Ling",
"givenName": "Ling",
"familyName": "Chen"
}
],
"titles": [
{
"title": "Booster vaccination is required to elicit and maintain COVID-19 vaccine-induced immunity in SIV-infected macaques"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Medicine"
},
{
"subject": "Microbiology"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Biotechnology"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Cancer"
},
{
"subject": "Mental Health"
},
{
"subject": "Infectious Diseases"
},
{
"subject": "FOS: Health sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Plant Biology"
},
{
"subject": "Virology"
},
{
"subject": "Computational Biology"
}
],
"contributors": [],
"dates": [
{
"date": "2023-03-01",
"dateType": "Created"
},
{
"date": "2023-10-23",
"dateType": "Updated"
},
{
"date": "2023",
"dateType": "Issued"
}
],
"publicationYear": 2023,
"identifiers": [],
"sizes": [
"91083406 Bytes"
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Prolonged infection and possible evolution of SARS-CoV-2 in patients living with uncontrolled HIV-1 infection highlight the importance of an effective vaccination regimen, yet the immunogenicity of COVID-19 vaccines and predictive immune biomarkers have not been well investigated. Herein, we report that the magnitude and persistence of antibody and cell-mediated immunity (CMI) elicited by an Ad5-vectored COVID-19 vaccine are impaired in SIV-infected macaques with high viral loads (> 105 genome copies per ml plasma, SIVhi) but not in macaques with low viral loads (< 105, SIVlow). After a second vaccination, the immune responses are robustly enhanced in all uninfected and SIVlow macaques. These responses also show a moderate increase in 70% SIVhi macaques but decline sharply soon after. Further analysis reveals that decreased antibody and CMI responses are associated with reduced circulating follicular helper T cell (TFH) counts and aberrant CD4/CD8 ratios, respectively, indicating that dysregulation of CD4+ T cells by SIV infection impairs the COVID-19 vaccine-induced immunity. Ad5-vectored COVID-19 vaccine shows no impact on SIV loads or SIV-specific CMI responses. Our study underscores the necessity of frequent booster vaccinations in HIV-infected patients and provides indicative biomarkers for predicting vaccination effectiveness in these patients.",
"descriptionType": "Abstract"
}
],
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"relationType": "IsSupplementTo",
"relatedIdentifier": "10.1080/22221751.2022.2136538",
"relatedIdentifierType": "DOI"
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