{
"id": "https://doi.org/10.6084/m9.figshare.21249462",
"doi": "10.6084/M9.FIGSHARE.21249462",
"url": "https://tandf.figshare.com/articles/journal_contribution/A_new_flavonol_derivative_and_other_compounds_from_the_leaves_of_i_Bauhinia_thonningii_i_Schum_with_activity_against_multidrug-resistant_bacteria/21249462",
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"creators": [
{
"name": "Nouemsi, Guy Raphael Sado",
"givenName": "Guy Raphael Sado",
"familyName": "Nouemsi"
},
{
"name": "Jouda, Jean-Bosco",
"givenName": "Jean-Bosco",
"familyName": "Jouda"
},
{
"name": "Leutcha, Peron Bosco",
"givenName": "Peron Bosco",
"familyName": "Leutcha"
},
{
"name": "Matieta, Valaire Yemene",
"givenName": "Valaire Yemene",
"familyName": "Matieta"
},
{
"name": "Tankeu, Virginie Flaure Tsague",
"givenName": "Virginie Flaure Tsague",
"familyName": "Tankeu"
},
{
"name": "Kuete, Jenifer Reine Ngnouzouba",
"givenName": "Jenifer Reine Ngnouzouba",
"familyName": "Kuete"
},
{
"name": "Çelik, İlhami",
"givenName": "İlhami",
"familyName": "Çelik"
},
{
"name": "Kuete, Victor",
"givenName": "Victor",
"familyName": "Kuete",
"affiliation": [
{
"name": "Johannes Gutenberg University of Mainz",
"affiliationIdentifier": "https://ror.org/023b0x485",
"affiliationIdentifierScheme": "ROR"
},
{
"name": "University of Dschang",
"affiliationIdentifier": "https://ror.org/0566t4z20",
"affiliationIdentifierScheme": "ROR"
}
]
},
{
"name": "Sewald, Norbert",
"givenName": "Norbert",
"familyName": "Sewald",
"affiliation": [
{
"name": "Bielefeld University",
"affiliationIdentifier": "https://ror.org/02hpadn98",
"affiliationIdentifierScheme": "ROR"
}
]
},
{
"name": "Lannang, Alain Meli",
"givenName": "Alain Meli",
"familyName": "Lannang"
}
],
"titles": [
{
"title": "A new flavonol derivative and other compounds from the leaves of Bauhinia thonningii Schum with activity against multidrug-resistant bacteria"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biochemistry"
},
{
"subject": "Medicine"
},
{
"subject": "Microbiology"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Pharmacology"
},
{
"subject": "Chemical Sciences not elsewhere classified",
"schemeUri": "http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E",
"subjectScheme": "ANZSRC Fields of Research",
"classificationCode": "39999"
},
{
"subject": "Cancer"
},
{
"subject": "Hematology"
},
{
"subject": "Infectious Diseases",
"schemeUri": "http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E",
"subjectScheme": "ANZSRC Fields of Research",
"classificationCode": "110309"
},
{
"subject": "FOS: Health sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Virology",
"schemeUri": "http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E",
"subjectScheme": "ANZSRC Fields of Research",
"classificationCode": "60506"
}
],
"contributors": [],
"dates": [
{
"date": "2022-09-30",
"dateType": "Created"
},
{
"date": "2023-07-25",
"dateType": "Updated"
},
{
"date": "2022",
"dateType": "Issued"
}
],
"publicationYear": 2022,
"identifiers": [],
"sizes": [
"1647422 Bytes"
],
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Investigation of the leaves of Bauhinia thonningii Schum led to the isolation and identification of a new flavonol derivative, 6-C-methylquercetin-3,4'-dimethyl ether (1) together with eleven known compounds (2–13), with two of them (10 and 11) obtained as a mixture. Their structures were established by extensive spectroscopic analyses. Antibacterial activity of compound 1 as well as the reference antibiotic, ciprofloxacin was tested on Gram-negative multidrug-resistant bacteria overexpressing active efflux pumps, and against methicillin-resistant strains of Staphylococcus aureus (MRSA). Samples were tested alone and in combination with an efflux pump inhibitor (EPI), phenylalanine-arginine-β-naphthylamide (PAßN). Results show that when compound 1 was tested alone, its inhibitory effects were obtained on 7/10 tested bacteria with the highest MIC value of 128 µg/mL whilst in the presence of EPI, this activity significantly increase in all the 10 bacteria. An interesting antibacterial activity was obtained with compound 1 against Klebsiella pneumoniae ATCC11296 (MIC of 4 µg/mL), KP55 and Staphylococcus aureus MRSA6 in the presence of the PaßN.",
"descriptionType": "Abstract"
}
],
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"relatedIdentifier": "10.1080/14786419.2022.2128347",
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