{
"id": "https://doi.org/10.6084/m9.figshare.19425167.v1",
"doi": "10.6084/M9.FIGSHARE.19425167.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/Identification_and_potential_mechanism_of_different_components_from_the_aerial_part_of_i_Bupleurum_chinense_i_DC_for_epileptic_treatment/19425167/1",
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"creators": [
{
"name": "Li, Xiaomao",
"givenName": "Xiaomao",
"familyName": "Li"
},
{
"name": "Liu, Yan",
"givenName": "Yan",
"familyName": "Liu"
},
{
"name": "Wang, Siyi",
"givenName": "Siyi",
"familyName": "Wang"
},
{
"name": "Guan, Wei",
"givenName": "Wei",
"familyName": "Guan"
},
{
"name": "Pan, Juan",
"givenName": "Juan",
"familyName": "Pan"
},
{
"name": "Kuang, Haixue",
"givenName": "Haixue",
"familyName": "Kuang"
},
{
"name": "Yang, Bingyou",
"givenName": "Bingyou",
"familyName": "Yang"
}
],
"titles": [
{
"title": "Identification and potential mechanism of different components from the aerial part of Bupleurum chinense DC. for epileptic treatment"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biochemistry"
},
{
"subject": "Cell Biology"
},
{
"subject": "Physiology"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Pharmacology"
},
{
"subject": "Biotechnology"
},
{
"subject": "Chemical Sciences not elsewhere classified"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Developmental Biology"
},
{
"subject": "Hematology"
}
],
"contributors": [],
"dates": [
{
"date": "2022-03-26",
"dateType": "Created"
},
{
"date": "2024-02-06",
"dateType": "Updated"
},
{
"date": "2022",
"dateType": "Issued"
}
],
"publicationYear": 2022,
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
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],
"descriptions": [
{
"description": "The present study aimed to assess the effects of epileptic treatment of the aerial part of Bupleurum chinense DC. in kainic acid (KA)-induced epilepsy rats and LPS-induced BV2 cells, as well as to identify the active chemical constituents. The in vivo and vitro results showed that 20% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-20) and 70% ethanol elution fractions of the aerial part of B. chinense DC. (BCE-70) could improve the epileptic state of the rats and status epilepticus (SE%). Moreover, ultra-high-performance liquid chromatography (UPLC)-Orbitrap- mass spectrometry (MS) analysis identified BCE-20 and 70 as flavonoids and phenylpropanoids, respectively. The mechanistic analysis also showed that BCE-20 and 70 could regulate neurotransmitter abnormalities and suppresses the expression and secretion of pro-inflammatory cytokines. Notably, BCE-20 and 70 could regulate the Triggering receptor expressed on myeloid cells 2 (TREM2)/nuclear factor-k-gene binding (NF-κB)/inhibitor of NF-κB α (IκBα) pathway to inhibit the neuroinflammation. Our findings support the ethnopharmacological use of the constituent polyphenols and flavonoids from the aerial part of B. chinense DC., as the strong anti-epileptic agents.",
"descriptionType": "Abstract"
}
],
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