{
"id": "https://doi.org/10.6084/m9.figshare.17821043.v1",
"doi": "10.6084/M9.FIGSHARE.17821043.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/Has_circ_0008583_modulates_hepatocellular_carcinoma_progression_through_the_miR-1301-3p_METTL3_pathway/17821043/1",
"types": {
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"creators": [
{
"name": "Wang, Fenfen",
"givenName": "Fenfen",
"familyName": "Wang"
},
{
"name": "Xie, Zhengyuan",
"givenName": "Zhengyuan",
"familyName": "Xie"
},
{
"name": "Zhang, Nuobei",
"givenName": "Nuobei",
"familyName": "Zhang"
},
{
"name": "Ding, Hao",
"givenName": "Hao",
"familyName": "Ding"
},
{
"name": "Xiong, Kai",
"givenName": "Kai",
"familyName": "Xiong"
},
{
"name": "Guo, Li",
"givenName": "Li",
"familyName": "Guo"
},
{
"name": "Huang, Hongyan",
"givenName": "Hongyan",
"familyName": "Huang"
},
{
"name": "Wen, Zhili",
"givenName": "Zhili",
"familyName": "Wen"
}
],
"titles": [
{
"title": "Has_circ_0008583 modulates hepatocellular carcinoma progression through the miR-1301-3p/METTL3 pathway"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biophysics"
},
{
"subject": "Biochemistry"
},
{
"subject": "Medicine"
},
{
"subject": "Genetics"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Molecular Biology"
},
{
"subject": "Physiology"
},
{
"subject": "Pharmacology"
},
{
"subject": "Chemical Sciences not elsewhere classified"
},
{
"subject": "Biological Sciences not elsewhere classified"
},
{
"subject": "Cancer"
},
{
"subject": "Statistics"
},
{
"subject": "FOS: Mathematics",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
}
],
"contributors": [],
"dates": [
{
"date": "2022-01-04",
"dateType": "Created"
},
{
"date": "2024-03-21",
"dateType": "Updated"
},
{
"date": "2022",
"dateType": "Issued"
}
],
"publicationYear": 2022,
"identifiers": [],
"sizes": [
"24325 Bytes"
],
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Has_circ_0008583 is reported to be involved in the progression of hepatocellular carcinoma (HCC), while its biological role in HCC remains unclear. Here, the qRT-PCR was used to detect the expression of has_circ_0008583. The CCK-8 kit was performed to measure cell proliferation. The cell migration and invasion were evaluated by Transwell. A dual-luciferase reporter assay was performed to confirm the target combination between the genes in has_circ_0008583/miR-1301-3p/METTL3 axis. The in vivo role of has_circ_0008583 was verified by murine xenograft assay. Our data showed that hsa_circ_0008583 was upregulated in HCC tissues and cells. Hsa_circ_0008583 overexpression promoted Hep3B cell proliferation, migration and invasion, but hsa_circ_0008583 silencing had an opposing influence. MiR-1301-3p is directly bound to hsa_circ_0008583 and METTL3. MiR-1301-3p overexpression or METTL3 knockdown could partially counteract hsa_circ_0008583 overexpression-mediated influence on HCC cell behaviors. In addition, hsa_circ_0008583 depletion inhibits HCC tumor growth in vivo. In conclusion, hsa_circ_0008583 promotes HCC progression through the miR-1301-3p/METTL3 axis.",
"descriptionType": "Abstract"
}
],
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"relatedIdentifier": "10.1080/21655979.2021.2017579",
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