{
"id": "https://doi.org/10.6084/m9.figshare.17064765.v1",
"doi": "10.6084/M9.FIGSHARE.17064765.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/Compound_Danshen_Dripping_Pill_inhibits_high_altitude-induced_hypoxic_damage_by_suppressing_oxidative_stress_and_inflammatory_responses/17064765/1",
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"creators": [
{
"name": "Hu, Yunhui",
"givenName": "Yunhui",
"familyName": "Hu"
},
{
"name": "Sun, Jia",
"givenName": "Jia",
"familyName": "Sun"
},
{
"name": "Wang, Tongxing",
"givenName": "Tongxing",
"familyName": "Wang"
},
{
"name": "Wang, Hairong",
"givenName": "Hairong",
"familyName": "Wang"
},
{
"name": "Zhao, Chunlai",
"givenName": "Chunlai",
"familyName": "Zhao"
},
{
"name": "Wang, Wenjia",
"givenName": "Wenjia",
"familyName": "Wang"
},
{
"name": "Yan, Kaijing",
"givenName": "Kaijing",
"familyName": "Yan"
},
{
"name": "Yan, Xijun",
"givenName": "Xijun",
"familyName": "Yan"
},
{
"name": "Sun, He",
"givenName": "He",
"familyName": "Sun"
}
],
"titles": [
{
"title": "Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biochemistry"
},
{
"subject": "Cell Biology"
},
{
"subject": "Molecular Biology"
},
{
"subject": "Physiology"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Pharmacology"
},
{
"subject": "Chemical Sciences not elsewhere classified"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Biological Sciences not elsewhere classified"
},
{
"subject": "Marine Biology"
}
],
"contributors": [],
"dates": [
{
"date": "2021-11-22",
"dateType": "Created"
},
{
"date": "2024-03-21",
"dateType": "Updated"
},
{
"date": "2021",
"dateType": "Issued"
}
],
"publicationYear": 2021,
"identifiers": [],
"sizes": [
"14459 Bytes"
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
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],
"descriptions": [
{
"description": "Previous studies indicate that compound Danshen Dripping Pill (CDDP) improves the adaptation to high-altitude exposure. However, its mechanism of action is not clear. To explore the protective effect of CDDP on hypobaric hypoxia (HH) and its possible mechanism. A meta-analysis of 1051 human volunteers was performed to evaluate the effectiveness of CDDP at high altitudes. Male Sprague-Dawley rats were randomized into 5 groups (n = 6): control at normal pressure, model, CDDP-170 mg/kg, CDDP-340 mg/kg and acetazolamide groups. HH was simulated at an altitude of 5500 m for 24 h. Animal blood was collected for arterial blood-gas analysis and cytokines detection and their organs were harvested for pathological examination. Expression levels of AQP1, NF-κB and Nrf2 were determined by immunohistochemical staining. The meta-analysis data indicated that the ratio between the combined RR of the total effective rate and the 95% CI was 0.23 (0.06, 0.91), the SMD and 95% CI of SO2 was 0.37 (0.12, 0.62). Pre-treatment of CDDP protected rats from HH-induced pulmonary edoema and heart injury, left-shifted oxygen-dissociation curve and decreased P50 (30.25 ± 3.72 vs. 37.23 ± 4.30). Mechanistically, CDDP alleviated HH-reinforced ROS by improving SOD and GPX1 while inhibiting pro-inflammatory cytokines and NF-κB expression. CDDP also decreased HH-evoked D-dimer, erythrocyte aggregation and blood hemorheology, promoting AQP1 and Nrf2 expression. Pre-treatment with CDDP could prevent HH-induced tissue damage, oxidative stress and inflammatory response. Suppressed NF-κB and up-regulated Nrf2 might play significant roles in the mechanism of CDDP.",
"descriptionType": "Abstract"
}
],
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