{
"id": "https://doi.org/10.6084/m9.figshare.16823079.v2",
"doi": "10.6084/M9.FIGSHARE.16823079.V2",
"url": "https://tandf.figshare.com/articles/dataset/M_sup_6_sup_A-mediated_up-regulation_of_LncRNA_LIFR-AS1_enhances_the_progression_of_pancreatic_cancer_via_miRNA-150-5p_VEGFA_Akt_signaling/16823079/2",
"types": {
"ris": "DATA",
"bibtex": "misc",
"citeproc": "dataset",
"schemaOrg": "Dataset",
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},
"creators": [
{
"name": "Chen, Jian-Qing",
"givenName": "Jian-Qing",
"familyName": "Chen"
},
{
"name": "Tao, Yuan-Ping",
"givenName": "Yuan-Ping",
"familyName": "Tao"
},
{
"name": "Hong, Yong-Gang",
"givenName": "Yong-Gang",
"familyName": "Hong",
"affiliation": [
{
"name": "Second Military Medical University",
"affiliationIdentifier": "https://ror.org/04tavpn47",
"affiliationIdentifierScheme": "ROR"
}
]
},
{
"name": "Li, Hui-Fen",
"givenName": "Hui-Fen",
"familyName": "Li"
},
{
"name": "Huang, Zhi-Ping",
"givenName": "Zhi-Ping",
"familyName": "Huang"
},
{
"name": "Xu, Xuan-Fu",
"givenName": "Xuan-Fu",
"familyName": "Xu"
},
{
"name": "Hu, Liang-Kai",
"givenName": "Liang-Kai",
"familyName": "Hu"
}
],
"titles": [
{
"title": "M6A-mediated up-regulation of LncRNA LIFR-AS1 enhances the progression of pancreatic cancer via miRNA-150-5p/ VEGFA/Akt signaling"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biochemistry"
},
{
"subject": "Medicine"
},
{
"subject": "Cell Biology"
},
{
"subject": "Molecular Biology"
},
{
"subject": "Pharmacology"
},
{
"subject": "69999 Biological Sciences not elsewhere classified",
"schemeUri": "http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E",
"subjectScheme": "FOR"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Developmental Biology"
},
{
"subject": "Cancer"
},
{
"subject": "Hematology"
}
],
"contributors": [],
"dates": [
{
"date": "2022-10-10",
"dateType": "Created"
},
{
"date": "2022-10-10",
"dateType": "Updated"
},
{
"date": "2022",
"dateType": "Issued"
}
],
"publicationYear": 2022,
"identifiers": [],
"sizes": [
"391198 Bytes"
],
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "N6-methyladenosine (m6A) modification, the most abundant internal methylation of eukaryotic RNA transcripts, is critically implicated in RNA processing. There is extensive evidence indicating that long non-coding RNAs (lncRNAs) serve as key regulators of oncogenesis and tumor progression in humans. Through prior study has assessed that LIFR-AS1 plays a key role in various kinds of malignant tumors. However, the exact role of m6A induced LIFR-AS1 in pancreatic cancer (PC) and its potential molecular mechanisms remain largely unknown. In this study, we determined that PC cell lines and tumors exhibit increased LIFR-AS1 expression that correlates with larger tumor size, lymph node metastasis, and more advanced TNM stage. Functionally, loss-of-function studies indicated that LIFR-AS1 knockdown decreased the proliferation, migration, and invasion of PC cells in vitro. Mechanistically, we found that METTL3 induced m6A hyper-methylation on the 3′ UTR of LIFR-AS1 to enhance its mRNA stability and LIFR-AS1 could directly interact with miR-150-5p, thereby indirectly up-regulating VEGFA expressions within cells. Through rescue experiments, we were able to confirm that the unfavorable impact of LIFR-AS1 knockdown on VEGFA /PI3K/Akt Signaling could be reversed via the inhibition of miR-150-5p expression. Together, these findings indicate that a noval m6A-LIFR-AS1 axis promotes PC progression at least in part via regulation of the miR-150-5p/VEGFA axis, indicating that this regulatory axis may be a viable clinical target for the treatment of PC.",
"descriptionType": "Abstract"
}
],
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"relatedIdentifier": "10.1080/15384101.2021.1991122",
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