{
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"doi": "10.6084/M9.FIGSHARE.15123593",
"url": "https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_anti-proliferative_activities_of_5_6_7-trimethoxyflavones_and_their_derivatives/15123593",
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"creators": [
{
"name": "Su, Liang",
"givenName": "Liang",
"familyName": "Su"
},
{
"name": "Li, Wei",
"givenName": "Wei",
"familyName": "Li"
},
{
"name": "Liu, Kexiong",
"givenName": "Kexiong",
"familyName": "Liu"
},
{
"name": "Wang, Qiuan",
"givenName": "Qiuan",
"familyName": "Wang"
}
],
"titles": [
{
"title": "Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Biochemistry"
},
{
"subject": "Pharmacology"
},
{
"subject": "Environmental Sciences not elsewhere classified"
},
{
"subject": "Chemical Sciences not elsewhere classified"
},
{
"subject": "Biological Sciences not elsewhere classified"
},
{
"subject": "Cancer"
},
{
"subject": "Hematology"
}
],
"contributors": [],
"dates": [
{
"date": "2021-08-06",
"dateType": "Created"
},
{
"date": "2024-03-21",
"dateType": "Updated"
},
{
"date": "2021",
"dateType": "Issued"
}
],
"publicationYear": 2021,
"identifiers": [],
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"15709696 Bytes"
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.",
"descriptionType": "Abstract"
}
],
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"relatedIdentifier": "10.1080/14786419.2021.1961136",
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