{
"id": "https://doi.org/10.6084/m9.figshare.14447034.v1",
"doi": "10.6084/M9.FIGSHARE.14447034.V1",
"url": "https://tandf.figshare.com/articles/journal_contribution/High_Child-Pugh_and_CRUB65_scores_predict_mortality_of_decompensated_cirrhosis_patients_with_COVID-19_A_23-center_retrospective_study/14447034/1",
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"creators": [
{
"name": "Xiao, Yong",
"givenName": "Yong",
"familyName": "Xiao"
},
{
"name": "Wu, Dongwen",
"givenName": "Dongwen",
"familyName": "Wu"
},
{
"name": "Shi, Xiao",
"givenName": "Xiao",
"familyName": "Shi"
},
{
"name": "Liu, Shuzhong",
"givenName": "Shuzhong",
"familyName": "Liu"
},
{
"name": "Hu, Xudong",
"givenName": "Xudong",
"familyName": "Hu"
},
{
"name": "Zhou, Chenliang",
"givenName": "Chenliang",
"familyName": "Zhou"
},
{
"name": "Tian, Xia",
"givenName": "Xia",
"familyName": "Tian"
},
{
"name": "Liu, Huimin",
"givenName": "Huimin",
"familyName": "Liu"
},
{
"name": "Long, Hui",
"givenName": "Hui",
"familyName": "Long"
},
{
"name": "Li, Zhihong",
"givenName": "Zhihong",
"familyName": "Li"
},
{
"name": "Wang, Ji",
"givenName": "Ji",
"familyName": "Wang"
},
{
"name": "Tan, Tao",
"givenName": "Tao",
"familyName": "Tan"
},
{
"name": "Xu, Ying",
"givenName": "Ying",
"familyName": "Xu"
},
{
"name": "Chen, Bitao",
"givenName": "Bitao",
"familyName": "Chen"
},
{
"name": "Liu, Ting",
"givenName": "Ting",
"familyName": "Liu"
},
{
"name": "Zhang, Heng",
"givenName": "Heng",
"familyName": "Zhang"
},
{
"name": "Zheng, Shihua",
"givenName": "Shihua",
"familyName": "Zheng"
},
{
"name": "Hu, Shunlin",
"givenName": "Shunlin",
"familyName": "Hu"
},
{
"name": "Song, Jun",
"givenName": "Jun",
"familyName": "Song"
},
{
"name": "Tang, Jie",
"givenName": "Jie",
"familyName": "Tang"
},
{
"name": "Song, Jichun",
"givenName": "Jichun",
"familyName": "Song"
},
{
"name": "Cheng, Zhengwei",
"givenName": "Zhengwei",
"familyName": "Cheng"
},
{
"name": "Xu, Weitian",
"givenName": "Weitian",
"familyName": "Xu"
},
{
"name": "Shen, Yongxiang",
"givenName": "Yongxiang",
"familyName": "Shen"
},
{
"name": "Yu, Wenhu",
"givenName": "Wenhu",
"familyName": "Yu"
},
{
"name": "Xu, Yong",
"givenName": "Yong",
"familyName": "Xu"
},
{
"name": "Li, Jiao",
"givenName": "Jiao",
"familyName": "Li"
},
{
"name": "Zhou, Jing",
"givenName": "Jing",
"familyName": "Zhou"
},
{
"name": "Wang, Fen",
"givenName": "Fen",
"familyName": "Wang"
},
{
"name": "Chen, Mingkai",
"givenName": "Mingkai",
"familyName": "Chen"
}
],
"titles": [
{
"title": "High Child-Pugh and CRUB65 scores predict mortality of decompensated cirrhosis patients with COVID-19: A 23-center, retrospective study"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Medicine"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Biological Sciences not elsewhere classified"
},
{
"subject": "Cancer"
},
{
"subject": "Science Policy"
},
{
"subject": "Mental Health"
},
{
"subject": "Infectious Diseases"
},
{
"subject": "FOS: Health sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
}
],
"contributors": [],
"dates": [
{
"date": "2021-04-19",
"dateType": "Created"
},
{
"date": "2024-03-21",
"dateType": "Updated"
},
{
"date": "2021",
"dateType": "Issued"
}
],
"publicationYear": 2021,
"identifiers": [],
"sizes": [
"9943 Bytes"
],
"formats": [],
"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Background: COVID-19 has rapidly become a major health emergency worldwide. The characteristic, outcome, and risk factor of COVID-19 in patients with decompensated cirrhosis remain unclear. Methods: Medical records were collected from 23 Chinese hospitals. Patients with decompensated cirrhosis and age- and sex-matched non-liver disease patients were enrolled with 1:4 ratio using stratified sampling. Results: There were more comorbidities with higher Chalson Complication Index (p < 0.001), higher proportion of patients having gastrointestinal bleeding, jaundice, ascites, and diarrhea among those patients (p < 0.05) and in decompensated cirrhosis patients. Mortality (p < 0.05) and the proportion of severe ill (p < 0.001) were significantly high among those patients. Patients in severe ill subgroup had higher mortality (p < 0.001), MELD, and CRUB65 score but lower lymphocytes count. Besides, this subgroup had larger proportion of patients with abnormal (PT), activated partial thromboplatin time (APTT), D-Dimer, alanine aminotransferase (ALT), aspartate aminotransferase (AST), total bilirubin (TBL) and Creatinine (Cr) (p < 0.05). Multivariate logistic regression for severity shown that MELD and CRUB65 score reached significance. Higher Child-Pugh and CRUB65 scores were found among non-survival cases and multivariate logistic regression further inferred risk factors for adverse outcome. Receiver Operating Characteristic (ROC) curves also provided remarkable demonstrations for the predictive ability of Child-Pugh and CRUB65 scores. Conclusions: COVID-19 patients with cirrhosis had larger proportion of more severely disease and higher mortality. MELD and CRUB65 score at hospital admission may predict COVID-19 severity while Child-Pugh and CRUB65 score were highly associated with non-survival among those patients.",
"descriptionType": "Abstract"
}
],
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