{
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"url": "https://tandf.figshare.com/articles/figure/High_anal_swab_viral_load_predisposes_adverse_clinical_outcomes_in_severe_COVID-19_patients/13488216/1",
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"creators": [
{
"name": "Li, Haibo",
"givenName": "Haibo",
"familyName": "Li"
},
{
"name": "Ren, Lili",
"givenName": "Lili",
"familyName": "Ren"
},
{
"name": "Zhang, Lulu",
"givenName": "Lulu",
"familyName": "Zhang"
},
{
"name": "Wang, Yeming",
"givenName": "Yeming",
"familyName": "Wang"
},
{
"name": "Guo, Li",
"givenName": "Li",
"familyName": "Guo"
},
{
"name": "Wang, Conghui",
"givenName": "Conghui",
"familyName": "Wang"
},
{
"name": "Xiao, Yan",
"givenName": "Yan",
"familyName": "Xiao"
},
{
"name": "Wang, Ying",
"givenName": "Ying",
"familyName": "Wang"
},
{
"name": "Rao, Jian",
"givenName": "Jian",
"familyName": "Rao"
},
{
"name": "Wang, Xinming",
"givenName": "Xinming",
"familyName": "Wang"
},
{
"name": "Liu, Ying",
"givenName": "Ying",
"familyName": "Liu"
},
{
"name": "Huang, Chaolin",
"givenName": "Chaolin",
"familyName": "Huang"
},
{
"name": "Gu, Xiaoying",
"givenName": "Xiaoying",
"familyName": "Gu"
},
{
"name": "Fan, Guohui",
"givenName": "Guohui",
"familyName": "Fan"
},
{
"name": "Li, Hui",
"givenName": "Hui",
"familyName": "Li"
},
{
"name": "Lu, Binghuai",
"givenName": "Binghuai",
"familyName": "Lu"
},
{
"name": "Cao, Bin",
"givenName": "Bin",
"familyName": "Cao"
},
{
"name": "Wang, Jianwei",
"givenName": "Jianwei",
"familyName": "Wang"
}
],
"titles": [
{
"title": "High anal swab viral load predisposes adverse clinical outcomes in severe COVID-19 patients"
}
],
"publisher": {
"name": "Taylor & Francis"
},
"container": {},
"subjects": [
{
"subject": "Medicine"
},
{
"subject": "Microbiology"
},
{
"subject": "FOS: Biological sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Biotechnology"
},
{
"subject": "Immunology"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Cancer"
},
{
"subject": "Science Policy"
},
{
"subject": "Mental Health"
},
{
"subject": "Infectious Diseases"
},
{
"subject": "FOS: Health sciences",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
},
{
"subject": "Virology"
}
],
"contributors": [],
"dates": [
{
"date": "2020-12-24",
"dateType": "Created"
},
{
"date": "2024-02-20",
"dateType": "Updated"
},
{
"date": "2020",
"dateType": "Issued"
}
],
"publicationYear": 2020,
"identifiers": [],
"sizes": [
"135423 Bytes"
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
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],
"descriptions": [
{
"description": "To identify the association between the kinetics of viral load and clinical outcome in severe coronavirus disease 2019 (COVID-19) patients, a retrospective study was performed by involved 188 hospitalized severe COVID-19 patients in the LOTUS China trial. Among the collected 578 paired throat swab (TS) and anal swab (AS) samples, viral RNA was detected in 193 (33.4%) TS and 121 (20.9%) AS. A higher viral RNA load was found in TS than that of AS, with means of 1.0 × 106 and 2.3 × 105 copies/ml, respectively. In non-survivors, the viral RNA in AS was detected earlier than that in survivors (median of 14 days vs 19 days, P = 0.007). The positivity and viral load in AS were higher in non-survivors than that of survivors at week 2 post symptom onset (P = 0.006). A high initial viral load in AS was associated with death (OR 1.368, 95% CI 1.076–1.741, P = 0.011), admission to the intensive care unit (OR 1.237, 95% CI 1.001–1.528, P = 0.049) and need for invasive mechanical ventilation (OR 1.340, 95% CI 1.076–1.669, P = 0.009). Our findings indicated viral replication in extrapulmonary sites should be monitored intensively during antiviral therapy.",
"descriptionType": "Abstract"
}
],
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"relatedIdentifier": "10.1080/22221751.2020.1858700",
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