{
"id": "https://doi.org/10.5281/zenodo.1344157",
"doi": "10.5281/ZENODO.1344157",
"url": "https://zenodo.org/record/1344157",
"types": {
"ris": "JOUR",
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"schemaOrg": "ScholarlyArticle",
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"creators": [
{
"name": "Dr. Aneeqa Nawaz, Dr. Bazgha Mushtaq, Dr Lubna Manzoor",
"nameType": "Personal",
"affiliation": []
}
],
"titles": [
{
"title": "End Stage Renal Disease (Esrd) Patient'S Assessment And Evaluation Of Pre And Post Dialysis Levels Of Interleukin-6 (Il – 6) And Leptin"
}
],
"publisher": {
"name": "Zenodo"
},
"container": {},
"subjects": [
{
"subject": "Interleukin-6 (IL – 6), Leptin and End Stage Renal Disease (ESRD)."
}
],
"contributors": [],
"dates": [
{
"date": "2018-08-12",
"dateType": "Issued"
}
],
"publicationYear": 2018,
"language": "en",
"identifiers": [
{
"identifier": "https://zenodo.org/record/1344158",
"identifierType": "URL"
}
],
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"rightsList": [
{
"rights": "Creative Commons Attribution 4.0",
"rightsUri": "https://creativecommons.org/licenses/by/4.0"
},
{
"rights": "Open Access",
"rightsUri": "info:eu-repo/semantics/openAccess"
}
],
"descriptions": [
{
"description": "Objective: Appetite can be controlled through “Leptin” which is the obese gene product. Our research aim was the pre and post level of leptin determination in the ESRD cases experiencing hemodialysis, in order to compare the level of pre serum leptin ESRD cases and healthy normal controls. Our research also determines the level of serum “IL – 6” before and after the experience of hemodialysis in ESRD cases.\n\nMethodology: Pre and post dialysis level of leptin was measured in 78 patients who underwent hemodialysis with ESRD to normal healthy volunteers at Services Hospital, Lahore (February, 2016 to December, 2016). We also measured the level of “IL – 6” in ESRD cases pre and post dialysis.\n\nResults: Significant high level of mean leptin serum was observed in ESRD cases in comparison to the normal healthy controls with respective mean and SD values as (38.22 ± 6.25) and (7.1 ± 4.38) ng/ml, with a significant P-value as (< 0.01). Post dialysis level of leptin serum was more than the pre dialysis level of leptin serum level with respective mean and SD values as (44.78 ± 5.85) and (38.22 ± 6.25) ng/ml, with a significant P-value as (< 0.05). IL – 6 post dialysis level was more than the pre dialysis level respectively as (14.7 ± 4.6) and (9 ± 4.9) pg/ml, with respective P-value as (< 0.01).\n\nConclusion: Circulating leptin is cleared by kidneys in the human body. However, evaluation may be standardized through more research work in order to evaluate the increased leptin significance in the ESRD patients.\n\nKeywords: Interleukin-6 (IL – 6), Leptin and End Stage Renal Disease (ESRD).",
"descriptionType": "Abstract"
}
],
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"agency": "datacite",
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