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"name": "Gonçalves, André Nicolau Aquime",
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"name": "De Queiroz Cunha, Fernando",
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"name": "Camara, Niels Olsen",
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"name": "Nakaya, Helder",
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"givenName": "Helder",
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"dates": [
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"date": "2022",
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"description": "Our research group investigates the inflammatory process in different aspects, from the endogenous control of the process, the effectiveness of molecules for therapy, the mechanisms of action of xenobiotics and the inflammatory microenvironment in tumor genesis. In this way, we acquired expertise, carried out national and international collaborations and set up an equipment park within the Faculty of Pharmaceutical Sciences at USP (FCF-USP), which has allowed us to contribute to the formation of a critical mass and to international literature within these aspects. In the present project, we propose to investigate mechanisms of action of components of the products of burning (conventional cigarette smoke - CC) and of heating tobacco (heat not burn tobacco-HNBT steam) on immune processes, which are the basis of diseases related to smoking, such as rheumatoid arthritis (RA), inflammatory bowel disease (IBD) and multiple sclerosis (MS). HNBTs comprise electronic cigarettes (ecigs) recently proposed as harm reducers for smokers, as they have reduced concentrations of tobacco combustion products. However, ecigs release nicotine, similarly to CC, glycerine and propylene glycol. Furthermore, recent literature shows that other toxic products resulting from the heating of diluents and heating batteries are released during exposures, and the toxicity of these compounds is not properly known. This project will be carried out in models of exposure to tobacco products in vivo in models of disease in mice and in a C. elegans model; in vitro, using multidimensional and/or organoid cell models; and ex vivo in samples collected from animals submitted to experimental models of diseases and from patients with RA, IBD and MS. Cellular and molecular assays will be carried out to investigate the effects of tobacco products on innate and adaptive responses. Exposures to smoking products will be carried out in an internationally standardized exposure regime, in pulses to mimic exposure to smokers, and these will be characterized by chemical analyzes of the products released during exposures. Furthermore, it is proposed to provide clarifications on the toxicity of tobacco products to elementary and high school students, educators and students' parents, as a preventive measure for the non-adherence of young people to the different ecigs. The project will train undergraduate and graduate students with solid concepts in immunotoxicology, will publish relevant manuscripts in the literature, in particular regarding the investigation of routes not yet described and the real toxicity of tobacco products, will expand national and international collaborations, will provide clarification to society on the harm of smoking, and will set up an experimental center for exposure to tobacco products. Furthermore, the project aims to fill gaps in the literature on pharmacological and toxic mechanisms of action of nicotine on the cellular/molecular events to be studied in the project. I emphasize that the funds requested in the project are intended for the acquisition of consumables, third-party services and scholarships, as the infrastructure acquired over the years allows us to carry out the project. The project is part of the Graduate Program in Pharmacy – Pathophysiology and Toxicology – of the Faculty of Pharmaceutical Sciences (FCF-USP), grade 7 by CAPES assessment, and I am its coordinator for the period 2020-2024. ",
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