{
"id": "https://doi.org/10.25384/sage.c.6401779",
"doi": "10.25384/SAGE.C.6401779",
"url": "https://sage.figshare.com/collections/Apical_pulmonary_lesions_suspected_of_malignancy_visible_on_neck_CT_angiography_performed_for_acute_stroke_Prevalence_treatment_and_clinical_implications_the_PLEURA_study/6401779",
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"ris": "GEN",
"bibtex": "misc",
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"schemaOrg": "Collection",
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"creators": [
{
"name": "Dittrich, Tolga D",
"givenName": "Tolga D",
"familyName": "Dittrich"
},
{
"name": "Aujesky, Mara",
"givenName": "Mara",
"familyName": "Aujesky"
},
{
"name": "Rudin, Salome",
"givenName": "Salome",
"familyName": "Rudin"
},
{
"name": "Zietz, Annaelle",
"givenName": "Annaelle",
"familyName": "Zietz"
},
{
"name": "Wagner, Benjamin",
"givenName": "Benjamin",
"familyName": "Wagner"
},
{
"name": "Polymeris, Alexandros",
"givenName": "Alexandros",
"familyName": "Polymeris"
},
{
"name": "Altersberger, Valerian L",
"givenName": "Valerian L",
"familyName": "Altersberger"
},
{
"name": "Sinnecker, Tim",
"givenName": "Tim",
"familyName": "Sinnecker"
},
{
"name": "Gensicke, Henrik",
"givenName": "Henrik",
"familyName": "Gensicke"
},
{
"name": "Engelter, Stefan T",
"givenName": "Stefan T",
"familyName": "Engelter"
},
{
"name": "Lyrer, Philippe",
"givenName": "Philippe",
"familyName": "Lyrer",
"affiliation": [
{
"name": "University Hospital of Basel",
"affiliationIdentifier": "https://ror.org/04k51q396",
"affiliationIdentifierScheme": "ROR"
}
]
},
{
"name": "Hess, Viviane",
"givenName": "Viviane",
"familyName": "Hess"
},
{
"name": "Sutter, Raoul",
"givenName": "Raoul",
"familyName": "Sutter",
"affiliation": [
{
"name": "University Hospital of Basel",
"affiliationIdentifier": "https://ror.org/04k51q396",
"affiliationIdentifierScheme": "ROR"
},
{
"name": "University of Basel",
"affiliationIdentifier": "https://ror.org/02s6k3f65",
"affiliationIdentifierScheme": "ROR"
}
]
},
{
"name": "Nickel, Christian H",
"givenName": "Christian H",
"familyName": "Nickel"
},
{
"name": "Bonati, Leo H",
"givenName": "Leo H",
"familyName": "Bonati"
},
{
"name": "Fischer, Urs",
"givenName": "Urs",
"familyName": "Fischer"
},
{
"name": "Psychogios, Marios",
"givenName": "Marios",
"familyName": "Psychogios"
},
{
"name": "Katan, Mira",
"givenName": "Mira",
"familyName": "Katan"
},
{
"name": "De Marchis, Gian Marco",
"givenName": "Gian Marco",
"familyName": "De Marchis",
"affiliation": [
{
"name": "University Hospital of Basel",
"affiliationIdentifier": "https://ror.org/04k51q396",
"affiliationIdentifierScheme": "ROR"
}
]
}
],
"titles": [
{
"title": "Apical pulmonary lesions suspected of malignancy visible on neck CT angiography performed for acute stroke: Prevalence, treatment, and clinical implications – the PLEURA study"
}
],
"publisher": {
"name": "SAGE Journals"
},
"container": {},
"subjects": [
{
"subject": "Cardiology"
},
{
"subject": "Medicine"
},
{
"subject": "110904 Neurology and Neuromuscular Diseases",
"schemeUri": "http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E",
"subjectScheme": "FOR"
},
{
"subject": "FOS: Clinical medicine",
"schemeUri": "http://www.oecd.org/science/inno/38235147.pdf",
"subjectScheme": "Fields of Science and Technology (FOS)"
}
],
"contributors": [],
"dates": [
{
"date": "2023-01-26",
"dateType": "Created"
},
{
"date": "2023-01-26",
"dateType": "Updated"
},
{
"date": "2023",
"dateType": "Issued"
}
],
"publicationYear": 2023,
"identifiers": [],
"sizes": [],
"formats": [],
"rightsList": [
{
"rights": "Creative Commons Attribution 4.0 International",
"rightsUri": "https://creativecommons.org/licenses/by/4.0/legalcode",
"schemeUri": "https://spdx.org/licenses/",
"rightsIdentifier": "cc-by-4.0",
"rightsIdentifierScheme": "SPDX"
}
],
"descriptions": [
{
"description": "Background:Computed tomography angiography (CTA) of the supraaortic arteries is commonly used for acute stroke workup and may reveal apical pulmonary lesions (APL).Aim:To determine the prevalence, follow-up algorithms, and in-hospital outcomes of stroke patients with APL on CTA.Methods:We retrospectively included consecutive adult patients with ischemic stroke, transient ischemic attack, or intracerebral hemorrhage and available CTA at a tertiary hospital between January 2014 and May 2021. We reviewed all CTA reports for the presence of APL. APL were classified as malignancy suspicious or benign appearing based on radiological-morphological criteria. We performed regression analyses to investigate the impact of malignancy suspicious APL on different in-hospital outcome parameters.Results:Among 2715 patients, APL on CTA were found in 161 patients (5.9% [95%CI: 5.1–6.9]; 161/2715). Suspicion of malignancy was present in one third of patients with APL (36.0% [95%CI: 29.0–43.7]; 58/161), 42 of whom (72.4% [95%CI: 60.0–82.2]; 42/58) had no history of lung cancer or metastases. When performed, further investigations confirmed primary or secondary pulmonary malignancy in three-quarters (75.0% [95%CI: 50.5–89.8]; 12/16), with two patients (16.7% [95%CI: 4.7–44.8]; 2/12) receiving de novo oncologic therapy. In multivariable regression, the presence of radiologically malignancy suspicious APL was associated with higher NIHSS scores at 24 h (beta = 0.67, 95%CI: 0.28–1.06, p = 0.001) and all-cause in-hospital mortality (aOR = 3.83, 95%CI: 1.29–9.94, p = 0.01).Conclusions:One in seventeen patients shows APL on CTA, of which one-third is malignancy suspicious. Further work-up confirmed pulmonary malignancy in a substantial number of patients triggering potentially life-saving oncologic therapy.",
"descriptionType": "Abstract"
}
],
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"fundingReferences": [],
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{
"relationType": "IsSupplementTo",
"relatedIdentifier": "10.1177/23969873231151488",
"relatedIdentifierType": "DOI"
}
],
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"providerId": "sage",
"clientId": "figshare.sage",
"agency": "datacite",
"state": "findable"
}