{
"@context": "http://schema.org",
"@type": "ScholarlyArticle",
"@id": "https://doi.org/10.6084/m9.figshare.19097628.v2",
"url": "https://tandf.figshare.com/articles/journal_contribution/Circular_RNA_0000654_facilitates_the_growth_of_gastric_cancer_cells_through_absorbing_microRNA-149-5p_to_up-regulate_inhibin-beta_A/19097628/2",
"additionalType": "Journal contribution",
"name": "Circular RNA 0000654 facilitates the growth of gastric cancer cells through absorbing microRNA-149-5p to up-regulate inhibin-beta A",
"author": [
{
"name": "Han Liu",
"givenName": "Han",
"familyName": "Liu"
},
{
"name": "Wen Dai",
"givenName": "Wen",
"familyName": "Dai"
}
],
"description": "Circular (circ) RNAs are differentially expressed in gastric cancer (GC) and participate in the biological growth of tumor cells. Given that, investigations were performed to unravel the function of circ_0000654 in GC. GC tissue and normal tissue specimens were obtained, in which circ_0000654, microRNA (miR)-149-5p, and inhibin-beta A (INHBA) levels were examined. GC cell line (BGC-823) was transfected to alter circ_0000654 and miR-149-5p expression, thereby observing cell malignancy. Stably-transfected BGC-823 cells were injected into nude mice to observe tumor growth in vivo. The interaction circ_0000654, miR-149-5p, and INHBA was validated. circ_0000654 and INHBA were up-regulated but miR-149-5p was down-regulated in GC. circ_0000654 absorbed miR-149-5p to target INHBA. Silencing circ_0000654inhibited the progress of GC cell biology. Oppositely, restoring circ_0000654 enhanced the growth of GC cells. Inhibiting miR-149-5p rescued down-regulated circ_0000654-induced anti-tumor effect on GC. circ_0000654 silence or miR-149-5p overexpression limited the growth of GC tumors in vivo. Obviously, circ_0000654 facilitates the growth of GC cells through absorbing miR-149-5p to up-regulate INHBA.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Biophysics, Biochemistry, Cell Biology, Genetics, FOS: Biological sciences, Molecular Biology, Physiology, Pharmacology, Chemical Sciences not elsewhere classified, Immunology, FOS: Clinical medicine, Developmental Biology, Cancer, Inorganic Chemistry, FOS: Chemical sciences, Statistics, FOS: Mathematics",
"contentSize": "13802 Bytes",
"dateCreated": "2022-02-16",
"datePublished": "2022",
"dateModified": "2024-03-21",
"sameAs": {
"@id": "https://doi.org/10.6084/m9.figshare.19097628",
"@type": "CreativeWork"
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"@reverse": {
"isBasedOn": {
"@id": "https://doi.org/10.1080/21655979.2021.2009414",
"@type": "ScholarlyArticle"
}
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"publisher": {
"@type": "Organization",
"name": "Taylor & Francis"
},
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"@type": "Organization",
"name": "datacite"
}
}