{
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"@id": "https://doi.org/10.6084/m9.figshare.15123593",
"url": "https://tandf.figshare.com/articles/journal_contribution/Synthesis_and_anti-proliferative_activities_of_5_6_7-trimethoxyflavones_and_their_derivatives/15123593",
"additionalType": "Journal contribution",
"name": "Synthesis and anti-proliferative activities of 5,6,7-trimethoxyflavones and their derivatives",
"author": [
{
"name": "Liang Su",
"givenName": "Liang",
"familyName": "Su"
},
{
"name": "Wei Li",
"givenName": "Wei",
"familyName": "Li"
},
{
"name": "Kexiong Liu",
"givenName": "Kexiong",
"familyName": "Liu"
},
{
"name": "Qiuan Wang",
"givenName": "Qiuan",
"familyName": "Wang"
}
],
"description": "A series of 5,6,7-trimethoxyflavones 1a-1g and their derivatives 2a-2g, 3a-3d, 4 and 5, including the natural products 5,6,7-trimethoxy-4’-hydroxyflavone (1a), 5,6,7,3’,4’ -pentamethoxyflavone (sinensetin, 1 b), 5,6,7-trimethoxy-3’,4’-methyl enedioxy flavone (1c), 5,6,7,3’-tetramethoxy-4,5’-methylenedioxyflavone (1e), 5,6,7, 3’,4’,5’-hextamethoxyflavone (1 g), 5-hydroxy-3,4,2’,3’,4’-pentamethoxy chal-cone (2 b), 5,4’-dihydroxy-6,7-dimethoxy flavone (cirsimaritin, 3a) and 5-hydroxy-6,7,3’, 4’-tetramethoxyflavone (5-demethylsinensetin, 3 b), 3,5,6,7,3’,4’-hexamethoxyflavone (3-methoxysinensetin, 4) and 5’-hydroxy-3,6,7,3’,4’-pentamethoxyflavone (5) were synthesized. Their anti-proliferative activity in vitro was evaluated against a panel of four human cancer cell lines (Aspc-1, HCT-116, HepG-2 and SUN-5) by the CTG assay. The results showed that most of the synthetic compounds exhibited moderate to high anti-proliferative activities. In particular, compound 3c possess IC50 (5.30 μM) values below 10 μM against Aspc-1 cells and are worthy of further investigation.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Biochemistry, Pharmacology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Biological Sciences not elsewhere classified, Cancer, Hematology",
"contentSize": "15709696 Bytes",
"dateCreated": "2021-08-06",
"datePublished": "2021",
"dateModified": "2024-03-21",
"@reverse": {
"isBasedOn": {
"@id": "https://doi.org/10.1080/14786419.2021.1961136",
"@type": "ScholarlyArticle"
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"publisher": {
"@type": "Organization",
"name": "Taylor & Francis"
},
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"@type": "Organization",
"name": "datacite"
}
}