{
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"@id": "https://doi.org/10.6084/m9.figshare.14883130.v1",
"url": "https://tandf.figshare.com/articles/journal_contribution/Dynamics_in_perioperative_neutrophil-to-lymphocyte_platelet_ratio_as_a_predictor_of_early_acute_kidney_injury_following_cardiovascular_surgery/14883130/1",
"additionalType": "Journal contribution",
"name": "Dynamics in perioperative neutrophil-to-lymphocyte*platelet ratio as a predictor of early acute kidney injury following cardiovascular surgery",
"author": [
{
"name": "Yang Li",
"givenName": "Yang",
"familyName": "Li"
},
{
"name": "Zhouping Zou",
"givenName": "Zhouping",
"familyName": "Zou"
},
{
"name": "Yunlu Zhang",
"givenName": "Yunlu",
"familyName": "Zhang"
},
{
"name": "Bowen Zhu",
"givenName": "Bowen",
"familyName": "Zhu"
},
{
"name": "Yichun Ning",
"givenName": "Yichun",
"familyName": "Ning"
},
{
"name": "Bo Shen",
"givenName": "Bo",
"familyName": "Shen"
},
{
"name": "Chunsheng Wang",
"givenName": "Chunsheng",
"familyName": "Wang"
},
{
"name": "Zhe Luo",
"givenName": "Zhe",
"familyName": "Luo"
},
{
"name": "Jiarui Xu",
"givenName": "Jiarui",
"familyName": "Xu"
},
{
"name": "Xiaoqiang Ding",
"givenName": "Xiaoqiang",
"familyName": "Ding"
}
],
"description": "In this study, we applied a composite index of neutrophil-lymphocyte * platelet ratio (NLPR), and explore the significance of the dynamics of perioperative NLPR in predicting cardiac surgery-associated acute kidney injury (CSA-AKI). During July 1st and December 31th 2019, participants were prospectively derived from the ‘Zhongshan Cardiovascular Surgery Cohort’. NLPR was determined using neutrophil counts, lymphocyte and platelet count at the two-time points. Dose-response relationship analyses were applied to delineate the non-linear odds ratio (OR) of CSA-AKI in different NLPR levels. Then NLPRs were integrated into the generalized estimating equation (GEE) to predict the risk of AKI. Of 2449 patients receiving cardiovascular surgery, 838 (34.2%) cases developed CSA-AKI with stage 1 (n = 658, 26.9%), stage 2–3 (n = 180, 7.3%). Compared with non-AKI patients, both preoperative and postoperative NLPR were higher in AKI patients (1.1[0.8, 1.8] vs. 0.9[0.7,1.4], p < 0.001; 12.4[7.5, 20.0] vs. 10.1[6.4,16.7], p < 0.001). Such an effect was a ‘J’-shaped relationship: CSA-AKI’s risk was relatively flat until 1.0 of preoperative NLPR and increased rapidly afterward, with an odds ratio of 1.13 (1.06–1.19) per 1 unit. Similarly, patients whose postoperative NLPR value >11.0 were more likely to develop AKI with an OR of 1.02. Integrating the dynamic NLPRs into the GEE model, we found that the AUC was 0.806(95% CI 0.793–0.819), which was significantly higher than the AUC without NLPR (0.799, p < 0.001). Dynamics of perioperative NPLR is a promising marker for predicting acute kidney injury. It will facilitate AKI risk management and allow clinicians to intervene early so as to reverse renal damage.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Space Science, Medicine, Cell Biology, Physiology, FOS: Biological sciences, Immunology, FOS: Clinical medicine, Mathematical Sciences not elsewhere classified, Developmental Biology, Marine Biology",
"contentSize": "389249 Bytes",
"dateCreated": "2021-06-30",
"datePublished": "2021",
"dateModified": "2024-02-13",
"sameAs": {
"@id": "https://doi.org/10.6084/m9.figshare.14883130",
"@type": "CreativeWork"
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"isBasedOn": {
"@id": "https://doi.org/10.1080/0886022x.2021.1937220",
"@type": "ScholarlyArticle"
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"publisher": {
"@type": "Organization",
"name": "Taylor & Francis"
},
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"@type": "Organization",
"name": "datacite"
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}