{
"@context": "http://schema.org",
"@type": "Dataset",
"@id": "https://doi.org/10.6084/m9.figshare.13624046",
"url": "https://tandf.figshare.com/articles/dataset/Acute_Radiation_Syndrome-related_gene_expression_in_irradiated_peripheral_blood_cell_populations/13624046",
"additionalType": "Dataset",
"name": "Acute radiation syndrome-related gene expression in irradiated peripheral blood cell populations",
"author": [
{
"name": "Patrick Ostheim",
"givenName": "Patrick",
"familyName": "Ostheim",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/032000t02",
"name": "University of Ulm"
}
},
{
"name": "Alan Don Mallawaratchy",
"givenName": "Alan Don",
"familyName": "Mallawaratchy"
},
{
"name": "Thomas Müller",
"givenName": "Thomas",
"familyName": "Müller",
"affiliation": [
{
"@type": "Organization",
"@id": "https://ror.org/01226dv09",
"name": "University Hospital Regensburg"
},
{
"@type": "Organization",
"@id": "https://ror.org/025fw7a54",
"name": "Friedrich-Loeffler-Institut"
},
{
"@type": "Organization",
"@id": "https://ror.org/02k7v4d05",
"name": "University of Bern"
}
]
},
{
"name": "Simone Schüle",
"givenName": "Simone",
"familyName": "Schüle",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/032000t02",
"name": "University of Ulm"
}
},
{
"name": "Cornelius Hermann",
"givenName": "Cornelius",
"familyName": "Hermann",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/032000t02",
"name": "University of Ulm"
}
},
{
"name": "Tanja Popp",
"givenName": "Tanja",
"familyName": "Popp"
},
{
"name": "Stefan Eder",
"givenName": "Stefan",
"familyName": "Eder",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/032000t02",
"name": "University of Ulm"
}
},
{
"name": "Stephanie E. Combs",
"givenName": "Stephanie E.",
"familyName": "Combs",
"affiliation": [
{
"@type": "Organization",
"@id": "https://ror.org/00cfam450",
"name": "Helmholtz Zentrum München"
},
{
"@type": "Organization",
"@id": "https://ror.org/02kkvpp62",
"name": "Technical University of Munich"
},
{
"@type": "Organization",
"@id": "https://ror.org/04cdgtt98",
"name": "German Cancer Research Center"
}
]
},
{
"name": "Matthias Port",
"givenName": "Matthias",
"familyName": "Port",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/032000t02",
"name": "University of Ulm"
}
},
{
"name": "Michael Abend",
"givenName": "Michael",
"familyName": "Abend",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/032000t02",
"name": "University of Ulm"
}
}
],
"description": "In a nuclear or radiological event, an early diagnostic tool is needed to distinguish the worried well from those individuals who may later develop life-threatenFing hematologic acute radiation syndrome. We examined the contribution of the peripheral blood's cell populations on radiation-induced gene expression (GE) changes. EDTA-whole-blood from six healthy donors was X-irradiated with 0 and 4Gy and T-lymphocytes, B-lymphocytes, NK-cells and granulocytes were separated using immunomagnetic methods. GE were examined in cell populations and whole blood. The cell populations contributed to the total RNA amount with a ratio of 11.6 for T-lymphocytes, 1.2 for B-cells, 1.2 for NK-cells, 1.0 for granulocytes. To estimate the contribution of GE per cell population, the baseline (0Gy) and the radiation-induced fold-change in GE relative to unexposed was considered for each gene. The T-lymphocytes (74.8%/80.5%) contributed predominantly to the radiation-induced up-regulation observed for FDXR/DDB2 and the B-lymphocytes (97.1%/83.8%) for down-regulated POU2AF1/WNT3 with a similar effect on whole blood gene expression measurements reflecting a corresponding order of magnitude. T- and B-lymphocytes contributed predominantly to the radiation-induced up-regulation of FDXR/DDB2 and down-regulation of POU2AF1/WNT3. This study underlines the use of FDXR/DDB2 for biodosimetry purposes and POU2AF1/WNT3 for effect prediction of acute health effects.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Biophysics, Medicine, Cell Biology, Genetics, FOS: Biological sciences, Molecular Biology, 59999 Environmental Sciences not elsewhere classified, FOS: Earth and related environmental sciences, Immunology, FOS: Clinical medicine, 69999 Biological Sciences not elsewhere classified, Cancer, Hematology",
"contentSize": "4454987 Bytes",
"dateCreated": "2021-03-03",
"datePublished": "2021",
"dateModified": "2023-01-06",
"@reverse": {
"isBasedOn": {
"@id": "https://doi.org/10.1080/09553002.2021.1876953",
"@type": "ScholarlyArticle"
}
},
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "Taylor & Francis"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}