{
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"@type": "Dataset",
"@id": "https://doi.org/10.6084/m9.figshare.11829504.v2",
"url": "https://tandf.figshare.com/articles/dataset/Emergence_of_ST11-K47_and_ST11-K64_hypervirulent_carbapenem-resistant_i_Klebsiella_pneumoniae_i_in_bacterial_liver_abscesses_from_China_a_molecular_biological_and_epidemiological_study/11829504/2",
"additionalType": "Dataset",
"name": "Emergence of ST11-K47 and ST11-K64 hypervirulent carbapenem-resistant Klebsiella pneumoniae in bacterial liver abscesses from China: a molecular, biological, and epidemiological study",
"author": [
{
"name": "Qiwen Yang",
"givenName": "Qiwen",
"familyName": "Yang"
},
{
"name": "Xinmiao Jia",
"givenName": "Xinmiao",
"familyName": "Jia"
},
{
"name": "Menglan Zhou",
"givenName": "Menglan",
"familyName": "Zhou"
},
{
"name": "Hui Zhang",
"givenName": "Hui",
"familyName": "Zhang"
},
{
"name": "Wenhang Yang",
"givenName": "Wenhang",
"familyName": "Yang"
},
{
"name": "Timothy Kudinha",
"givenName": "Timothy",
"familyName": "Kudinha"
},
{
"name": "Yingchun Xu",
"givenName": "Yingchun",
"familyName": "Xu"
}
],
"description": "Background: Multidrug-resistant bacteria, especially those with high virulence, are an emerging problem in clinical settings. Methods: We conducted a multicentre epidemiological and comparative genomic analysis on the evolution, virulence and antimicrobial resistance of carbapenem-resistant Enterobacteriaceae in patients with bacterial liver abscesses from 2012 to 2016. Results: A total of 477 bacterial isolates were collected. Enterobacteriaceae were the main pathogen (89.3%) with K. pneumoniae (52.4%) predominating followed by Escherichia coli (26.8%). All CRKps (3.2%) were of sequence type (ST) 11 and serotypes K47 or K64, and simultaneously possessed acquired blaKPC-2/blaKPC-5 and blaCTX-M-65 together with the multidrug transporter EmrE. Seven Hv-CRKps (five ST11-K47, two ST11-K64) were confirmed by bacteriological test, neutrophil killing assay and Galleria mellonella infection model. Genomic analysis indicated that the emergence of one ST11-K64 Hv-CRKp strain was related to the acquisition of rmpA/rmpA2 genes and siderophore gene clusters, while ST11-K47 Hv-CRKp lacked these traditional virulence genes. Further complete genome analysis of one ST11-K47 Hv-CRKp strain, R16, showed that it acquired a rare plasmid (pR16-Hv-CRKp1) carrying blaKPC-2, blaSHV-12, blaTEM-1, blaCTX-M-65, rmtB and a predicted virulence gene R16_5486 simultaneously. Conclusion: The emergence of the ST11-K47/K64 Hv-CRKps, which are simultaneously multidrug-resistant and hypervirulent, requires urgent control measures to be implemented.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Space Science, Medicine, Microbiology, FOS: Biological sciences, Genetics, Biotechnology, Evolutionary Biology, Environmental Sciences not elsewhere classified, Chemical Sciences not elsewhere classified, Immunology, FOS: Clinical medicine, Biological Sciences not elsewhere classified, Cancer, Infectious Diseases, FOS: Health sciences, Virology",
"contentSize": "2412491 Bytes",
"dateCreated": "2021-09-29",
"datePublished": "2021",
"dateModified": "2024-02-15",
"predecessor_of": {
"@id": "https://doi.org/10.6084/m9.figshare.11829504",
"@type": "CreativeWork"
},
"@reverse": {
"isBasedOn": {
"@id": "https://doi.org/10.1080/22221751.2020.1721334",
"@type": "ScholarlyArticle"
}
},
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "Taylor & Francis"
},
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"@type": "Organization",
"name": "datacite"
}
}