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"name": "Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030.",
"author": [
{
"name": "Ranucci M",
"affiliation": {
"@type": "Organization",
"name": "Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy."
}
},
{
"name": " Aloisio T",
"familyName": "Aloisio T",
"affiliation": {
"@type": "Organization",
"name": "Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy."
}
},
{
"name": "Di Dedda U",
"givenName": "Di Dedda",
"familyName": "U",
"affiliation": {
"@type": "Organization",
"name": "Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy."
},
"@type": "Person"
},
{
"name": "Menicanti L",
"affiliation": {
"@type": "Organization",
"name": "Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan Italy."
}
},
{
"name": "De Vincentiis C",
"givenName": "De Vincentiis",
"familyName": "C",
"affiliation": {
"@type": "Organization",
"name": "Department of Cardiac Surgery, IRCCS Policlinico San Donato, Milan Italy."
},
"@type": "Person"
},
{
"name": "Baryshnikova E;",
"affiliation": {
"@type": "Organization",
"name": "Department of Cardiothoracic, Vascular Anaesthesia and Intensive Care, IRCCS Policlinico San Donato, Milan, Italy."
}
}
],
"description": "Data set from Ranucci M, Aloisio T, Di Dedda U, Menicanti L, de Vincentiis C, Baryshnikova E; Surgical and Clinical Outcome REsearch (SCORE) group. Gender-based differences in platelet function and platelet reactivity to P2Y12 inhibitors. PLoS One. 2019 Nov 27;14(11):e0225771. doi: 10.1371/journal.pone.0225771. PMID: 31774869; PMCID: PMC6881030. This is the article: Background: Gender influences platelet biology. Women have a larger platelet count, but gender-based differences in platelet function remain debated. We performed a study addressing gender-based differences in platelet function using point-of-care platelet function tests (PFT). Methods: The patient population consisted of 760 cardiac surgery patients where preoperative PFT (multiple-electrode aggregometry [MEA]) were available. Platelet count and function at the ADPtest and TRAPtest were compared in the overall population and separately in patients with or without residual effects of P2Y12 inhibitors. Results: Women had a significantly (P = 0.001) higher platelet count but a non-significantly higher platelet reactivity to ADP. In clopidogrel-treated patients, the platelets ADP reactivity was significantly (P = 0.031) higher in women, and platelet count was the main determinant of platelet hyper-reactivity. Within patients under full clopidogrel effects, women with a platelet count ≥ 200,000 cells/μL had a significantly (P = 0.023) higher rate of high-on-treatment platelet reactivity (HTPR, 45.5%) with respect to males with a platelet count < 200,000 cells/μL (11.9%), with a relative risk of 6.2 (95% confidence interval 1.4-29). Conclusions: Our findings confirm that women have a larger platelet count than men, and that this is associated to a trend towards a higher platelet reactivity. HTPR is largely represented in women with a high platelet count. This generates the hypothesis that women requiring P2Y12 inhibitors could potentially benefit from larger doses of drug or should be treated with anti-platelet agents with a low rate of HTPR.",
"license": "info:eu-repo/semantics/restrictedAccess",
"inLanguage": "en",
"datePublished": "2020-10-02",
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