{
"@context": "http://schema.org",
"@type": "ScholarlyArticle",
"@id": "https://doi.org/10.5281/zenodo.3970038",
"url": "https://zenodo.org/record/3970038",
"additionalType": "Journal article",
"name": "Statistical study of the relationship between hyperuricemia, dyslipidemia and type 2 diabetes in rural population of Tizi-Ouzou, Algeria",
"author": [
{
"name": "Khalef Lefsih",
"givenName": "Khalef",
"familyName": "Lefsih",
"affiliation": {
"@type": "Organization",
"name": "Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria"
},
"@id": "https://orcid.org/0000-0002-7661-2121"
},
{
"name": "Dalila Dahmani",
"givenName": "Dalila",
"familyName": "Dahmani",
"affiliation": {
"@type": "Organization",
"name": "Biochemistry laboratory, CHU Tizi-Ouzou, Algeria"
}
},
{
"name": "Rabah Cherrad",
"givenName": "Rabah",
"familyName": "Cherrad",
"affiliation": {
"@type": "Organization",
"name": "Epidemiology and preventive medicine department, CHU Tizi-Ouzou, Algeria"
}
},
{
"name": "Souad Lalaoui",
"givenName": "Souad",
"familyName": "Lalaoui",
"affiliation": {
"@type": "Organization",
"name": "Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria"
}
},
{
"name": "Sarah Amrara",
"givenName": "Sarah",
"familyName": "Amrara",
"affiliation": {
"@type": "Organization",
"name": "Biochemistry and microbiology department, FSBSA, University of Tizi-Ouzou, Algeria"
}
}
],
"description": "Aim : The main objective of our work was to assess the relationship between type 2 diabetes, hyperuricemia and dyslipidemia in the population of Tizi-Ouzou. By evaluating the relationship between hyperuricemia and some blood lipid parameters, we thus establish, in type 2 diabetes, the correlation between uremia and these lipid parameters. Subjects and methods: The survey was carried out by means of an individual questionnaire. We excluded from our study pregnant women, patients with cancer, patients with end-stage renal disease and subjects who did not respond to the questionnaire. Results: Serum uric acid level increased with age (p = 0.025). Hyperuricemia was associated with heart disease (p = 0.0007). All patients with gout presented an elevated serum uric acid (p = 0.000001). Dyslipidemia was more common in patients with elevated serum uric acid levels (p = 0.0008). Triglyceridemia was significantly associated with hyperuricemia (p = 0.025). The relationship between type 2 diabetes and glomerular filtration rate was not significant, while the latter was decreased in patients with elevated serum uric acid levels (p = 0.0001). In, stratified analysis, age was effect modifier, the age-dependent results make us understand that resistance to insulin constitutes a significant factor of hyperuricemia. Conclusion: The association between hyperuricemia and dyslipidemia in type 2 diabetes emphasizes that insulin resistance acts on both lipid parameters and uricemia. A diet correcting dyslipidemia may also correct the uricemia.",
"license": [
"https://creativecommons.org/licenses/by/4.0/legalcode",
"info:eu-repo/semantics/openAccess"
],
"keywords": "hyperuricemia, diabetes type 2, dyslipidemia, lipoproteins",
"datePublished": "2020-08-08",
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "Zenodo"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}