{
"@context": "http://schema.org",
"@type": "ScholarlyArticle",
"@id": "https://doi.org/10.25419/rcsi.10818125.v1",
"url": "https://repository.rcsi.com/articles/Mechanical_Insufflation_Exsufflation_and_Lung_Volume_Recruitment_in_Amyotrophic_Lateral_Sclerosis_a_Prospective_Study_of_the_Prescription_Process_the_Outcomes_and_the_Experience/10818125/1",
"additionalType": "Thesis",
"name": "Mechanical Insufflation Exsufflation and Lung Volume Recruitment in Amyotrophic Lateral Sclerosis: a Prospective Study of the Prescription Process, the Outcomes and the Experience",
"author": {
"name": "Rachel McConnell",
"givenName": "Rachel",
"familyName": "McConnell",
"@type": "Person"
},
"description": "Introduction: Mechanical Insufflation Exsufflation (M-IE) and Lung Volume Recruitment (LVR) increase cough strength in Amyotrophic Lateral Sclerosis (ALS). Changes in respiratory measures, morbidity, physical function and outcomes; participant’s characteristics prescribed a M-IE and LVR device and their experience with devices are unknown. Finally, LVR adherence is difficult to measure. Aims/Objectives: The primary aim was to measure, respiratory measures, morbidity, physical function and outcome in an Irish ALS cohort. Secondary aims were to examine the characteristics of participants prescribed a device; to evaluate their experiences and to develop an electronic LVR adherence prototype. Methods: A prospective longitudinal observational cohort study evaluated 108 participants over one year. Respiratory measures, physical function and outcomes were measured. Characteristics were assessed at device prescription. A questionnaire evaluated experience. An electronic LVR adherence prototype was developed. Results: Participants (n=108), of mean age 62.05±11.47, were recruited. Sniff Nasal Inspiratory Pressure (SNIP), Slow Vital Capacity (SVC) percent predicted, Peak Cough Flow (PCF) and Amyotrophic Lateral Sclerosis Functional Rating Scale Revised (ALSFRS-R) declined significantly (p2O, 17.49%, 124.84L/min and 9.62 units per year respectively. One third reported a chest infection and 21 died. Participants prescribed a device had significantly lower average SNIP, SVC percent predicted, PCF and ALSFRS-R (p Conclusion: This is the first study to quantify the rate of decline of SNIP, SVC and PCF in an Irish ALS cohort and PCF in a large ALS cohort. Device prescription is detailed. This study provides a point of reference for clinicians and future trials. The electronic LVR adherence prototype has potential to be developed for clinical trials.",
"license": "https://creativecommons.org/licenses/by-nc-sa/4.0",
"keywords": "Uncategorized",
"contentSize": "7709561 Bytes",
"dateCreated": "2019-11-23",
"datePublished": "2019",
"dateModified": "2019-11-23",
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"@id": "https://doi.org/10.25419/rcsi.10818125",
"@type": "CreativeWork"
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"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "Royal College of Surgeons in Ireland"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}