{
"@context": "http://schema.org",
"@type": "ScholarlyArticle",
"@id": "https://doi.org/10.25419/rcsi.10764104",
"url": "https://repository.rcsi.com/articles/thesis/Activation_of_the_resident_Skeletal_Stem_Cell_SSC_for_articular_cartilage_regeneration_/10764104",
"additionalType": "Thesis",
"name": "Activation of the resident Skeletal Stem Cell (SSC) for articular cartilage regeneration.",
"author": {
"name": "Matthew Philip Murphy",
"givenName": "Matthew Philip",
"familyName": "Murphy",
"@type": "Person"
},
"description": "The aim of this PhD thesis is to validate that a commonly performed surgical therapy used to treat patients with osteoarthritis (OA), microfracture (MF), can activate tissue-resident Skeletal Stem Cells (SSC) from distal femurs. In Chapter 1 we introduce the topics related to the thesis including; OA overview, stem cell therapies and current stem cell trials used for OA. In Chapter 2 we show that with age there is a reduction in the number of SSC in the articular surface of mouse distal femurs. In Chapter 3 we demonstrate that there is an local, transient activation of SSC following acute MF surgical stimulation. In Chapter 4 we show that augmentation of the niche with growth factors bone morphogenetic protein 2 (BMP2) and vascular endothelial growth factor receptor 1 (VEGFR1) following injury results in the regeneration of hyaline-like cartilage. In Chapter 5 we translate our mouse findings in vivo utilising our human xenograft model. In our human xenograft model we confirm that following acute injury there is a similar activation in tissue resident SSC. Niche augmentation with BMP2 and VEGFR1 in the human xenograft model leads to de novo human cartilage formation in a bone niche.",
"license": "https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode",
"keywords": "Medicine",
"contentSize": "16667862 Bytes",
"dateCreated": "2019-11-22",
"datePublished": "2020",
"dateModified": "2020-12-04",
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "Royal College of Surgeons in Ireland"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}