{
"@context": "http://schema.org",
"@type": "Collection",
"@id": "https://doi.org/10.25384/sage.c.6350376.v1",
"url": "https://sage.figshare.com/collections/Effectiveness_and_Safety_of_DOACs_in_Atrial_Fibrillation_Patients_Undergoing_Catheter_Ablation_Results_from_the_China_Atrial_Fibrillation_China-AF_Registry/6350376/1",
"additionalType": "Collection",
"name": "Effectiveness and Safety of DOACs in Atrial Fibrillation Patients Undergoing Catheter Ablation: Results from the China Atrial Fibrillation (China-AF) Registry",
"author": [
{
"name": "Zhimin Dong",
"givenName": "Zhimin",
"familyName": "Dong"
},
{
"name": "Xiaoxia Hou",
"givenName": "Xiaoxia",
"familyName": "Hou"
},
{
"name": "Xin Du",
"givenName": "Xin",
"familyName": "Du"
},
{
"name": "Liu He",
"givenName": "Liu",
"familyName": "He"
},
{
"name": "Jianzeng Dong",
"givenName": "Jianzeng",
"familyName": "Dong"
},
{
"name": "Changsheng Ma",
"givenName": "Changsheng",
"familyName": "Ma"
}
],
"description": "BackgroundDirect oral anticoagulants (DOACs) have increasingly become an alternative to warfarin in atrial fibrillation (AF) patients. Nonetheless, data on the effectiveness and safety of DOACs in periprocedural of catheter ablation (CA) in real-world practice was relatively rare.Methods and Results3385 AF patients underwent initial CA and never used oral anticoagulant before enrollment between April 2013 and December 2018 were involved from China Atrial Fibrillation (China-AF) Registry. Warfarin, rivaroxaban and dabigatran were used in 1896 (56.0%), 718 (21.2%), and 771 (22.8%) patients, respectively. Propensity score matching was used to balance covariates across study groups. No significant differences were observed in rivaroxaban-warfarin, dabigatran-warfarin and dabigatran-rivaroxaban cohort for thromboembolic (TE) and major bleeding (MB) incidence. Similar results were also revealed in low-dose rivaroxaban (RLD)-warfarin, low-dose dabigatran (DLD)-warfarin and DLD-RLD cohort. However, the risk of non-MB was higher not only on standard-dose of rivaroxaban but also on RLD when compared with warfarin and with DLD, respectively.ConclusionsIn this study, the incidence of TE and MB were both comparable in standard- or low-dose DOACs versus warfarin and between the two DOACs, whereas the risk of non-MB was higher in rivaroxaban than in warfarin and in RLD than in DLD.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Cardiology, Pharmacology and Pharmaceutical Sciences not elsewhere classified",
"dateCreated": "2022-12-18",
"datePublished": "2022",
"dateModified": "2022-12-18",
"sameAs": {
"@id": "https://doi.org/10.25384/sage.c.6350376",
"@type": "CreativeWork"
},
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "SAGE Journals"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}