{
"@context": "http://schema.org",
"@type": "Collection",
"@id": "https://doi.org/10.25384/sage.c.6339617.v1",
"url": "https://sage.figshare.com/collections/Preserved_T-cell_response_in_anti-CD20-treated_multiple_sclerosis_patients_following_SARS-CoV-2_vaccination/6339617/1",
"additionalType": "Collection",
"name": "Preserved T-cell response in anti-CD20-treated multiple sclerosis patients following SARS-CoV-2 vaccination",
"author": [
{
"name": "Simon Faissner",
"givenName": "Simon",
"familyName": "Faissner"
},
{
"name": "Neele Heitmann",
"givenName": "Neele",
"familyName": "Heitmann"
},
{
"name": "Ricarda Rohling",
"givenName": "Ricarda",
"familyName": "Rohling"
},
{
"name": "Ulas Ceylan",
"givenName": "Ulas",
"familyName": "Ceylan"
},
{
"name": "Marielena Bongert",
"givenName": "Marielena",
"familyName": "Bongert"
},
{
"name": "Carlos Plaza-Sirvent",
"givenName": "Carlos",
"familyName": "Plaza-Sirvent"
},
{
"name": "Corinna Marheinecke",
"givenName": "Corinna",
"familyName": "Marheinecke"
},
{
"name": "Xiomara Pedreiturria",
"givenName": "Xiomara",
"familyName": "Pedreiturria"
},
{
"name": "Ilya Ayzenberg",
"givenName": "Ilya",
"familyName": "Ayzenberg",
"affiliation": [
{
"@type": "Organization",
"@id": "https://ror.org/046vare28",
"name": "St. Josef-Hospital"
},
{
"@type": "Organization",
"@id": "https://ror.org/02yqqv993",
"name": "Sechenov University"
}
]
},
{
"name": "Kerstin Hellwig",
"givenName": "Kerstin",
"familyName": "Hellwig"
},
{
"name": "Ingo Schmitz",
"givenName": "Ingo",
"familyName": "Schmitz"
},
{
"name": "Stephanie Pfaender",
"givenName": "Stephanie",
"familyName": "Pfaender",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/04tsk2644",
"name": "Ruhr University Bochum"
}
},
{
"name": "Ralf Gold",
"givenName": "Ralf",
"familyName": "Gold",
"affiliation": {
"@type": "Organization",
"@id": "https://ror.org/04tsk2644",
"name": "Ruhr University Bochum"
}
}
],
"description": "Background:The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has tremendous implications for the management of patients with autoimmune conditions such as multiple sclerosis (MS) under immune therapies targeting CD20+ B cells (aCD20).Objectives:Here, we investigated humoral and cellular immune responses, including anti-spike titers, neutralization against SARS-CoV-2 wild-type (WT), delta, and omicron variant and T cell responses of aCD20-treated relapsing–remitting MS patients following SARS-CoV-2 vaccination compared with healthy controls.Methods:Blood samples were collected within 4–8 weeks following the second vaccination against SARS-CoV-2. Sera were analyzed for anti-SARS-CoV-2 spike antibodies and neutralization capacity against pseudovirus for wild-type (WT), delta, and omicron variant. Peripheral blood mononuclear cells (PBMCs) were stimulated with a SARS-CoV-2 peptide pool and analyzed via flow cytometry.Results:The aCD20-treated MS patients had lower anti-SARS-CoV-2-spike titers, which correlated with B cell repopulation. Sera of aCD20-treated patients had reduced capacity to neutralize WT, delta, and omicron pseudoviruses in vitro. On the contrary, PBMCs of aCD20-treated patients elicited higher frequencies of CD3+ T cells and CD4+ T cells and comparable response of cytotoxic T cells, while Th1 response was reduced following restimulation with SARS-CoV-2.Conclusion:In summary, aCD20-treated patients have a reduced humoral immune response, depending on B cell repopulation, in accordance with preserved cellular immune response, suggesting partial cellular protection against SARS-CoV-2.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "110904 Neurology and Neuromuscular Diseases, FOS: Clinical medicine, 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified",
"dateCreated": "2022-12-10",
"datePublished": "2022",
"dateModified": "2022-12-10",
"sameAs": {
"@id": "https://doi.org/10.25384/sage.c.6339617",
"@type": "CreativeWork"
},
"@reverse": {
"isBasedOn": {
"@id": "https://doi.org/10.1177/17562864221141505",
"@type": "ScholarlyArticle"
}
},
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "SAGE Journals"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}