{
"@context": "http://schema.org",
"@type": "Collection",
"@id": "https://doi.org/10.25384/sage.c.5120110",
"url": "https://sage.figshare.com/collections/Derivation_and_validation_of_a_prediction_rule_for_mortality_of_patients_with_respiratory_virus-related_pneumonia_RV-p_score_/5120110",
"additionalType": "Collection",
"name": "Derivation and validation of a prediction rule for mortality of patients with respiratory virus-related pneumonia (RV-p score)",
"author": [
{
"name": "Liang Chen",
"givenName": "Liang",
"familyName": "Chen"
},
{
"name": "Xiudi Han",
"givenName": "Xiudi",
"familyName": "Han"
},
{
"name": "YanLi Li",
"givenName": "YanLi",
"familyName": "Li"
},
{
"name": "Chunxiao Zhang",
"givenName": "Chunxiao",
"familyName": "Zhang"
},
{
"name": "Xiqian Xing",
"givenName": "Xiqian",
"familyName": "Xing"
}
],
"description": "Background:Respiratory viruses are important etiologies of community-acquired pneumonia. However, current knowledge on the prognosis of respiratory virus-related pneumonia (RV-p) is limited. Thus, here we aimed to establish a clinical predictive model for mortality of patients with RV-p.Methods:A total of 1431 laboratory-confirmed patients with RV-p, including 1169 and 262 patients from respective derivation and validation cohorts from five teaching hospitals in China were assessed between January 2010 and December 2019. A prediction rule was established on the basis of risk factors for 30-day mortality of patients with RV-p from the derivation cohort using a multivariate logistic regression model.Results:The 30-day mortality of patients with RV-p was 16.8% (241/1431). The RV-p score was composed of nine predictors (including respective points of mortality risk): (a) age ⩾65 years (1 point); (b) chronic obstructive pulmonary disease (1 point); (c) mental confusion (1 point); (d) blood urea nitrogen (1 point); (e) cardiovascular disease (2 points); (f) smoking history (2 points); (g) arterial pressure of oxygen/fraction of inspiration oxygen (PaO2/FiO2) < 250 mmHg (2 points); (h) lymphocyte counts <0.8 × 109/L (2 points); (i) arterial PH < 7.35 (3 points). A total of six points was used as the cut-off value for mortality risk stratification. Our model showed a sensitivity of 0.831 and a specificity of 0.783. The area under the receiver operating characteristic curve was more prominent for RV-p scoring [0.867, 95% confidence interval (CI)0.846–0.886] when compared with both pneumonia severity index risk (0.595, 95% CI 0.566–0.624, p < 0.001) and CURB-65 scoring (0.739, 95% CI 0.713–0.765, p < 0.001).Conclusion:RV-p scoring was able to provide a good predictive accuracy for 30-day mortality, which accounted for a more effective stratification of patients with RV-p into relevant risk categories and, consequently, help physicians to make more rational clinical decisions.The reviews of this paper are available via the supplemental material section.",
"license": "https://creativecommons.org/licenses/by/4.0/legalcode",
"keywords": "Aged Health Care, Pharmacology and Pharmaceutical Sciences not elsewhere classified, Respiratory Diseases",
"dateCreated": "2020-09-13",
"datePublished": "2020",
"dateModified": "2020-09-13",
"schemaVersion": "http://datacite.org/schema/kernel-4",
"publisher": {
"@type": "Organization",
"name": "SAGE Journals"
},
"provider": {
"@type": "Organization",
"name": "datacite"
}
}