{"data":{"id":"10.7272/q6rx997g","type":"dois","attributes":{"doi":"10.7272/q6rx997g","prefix":"10.7272","suffix":"q6rx997g","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wekerle, Hartmut","nameType":"Personal","givenName":"Hartmut","familyName":"Wekerle","affiliation":["Max Planck Institute of Neurobiology"],"nameIdentifiers":[]},{"name":"Berer, Kerstin","nameType":"Personal","givenName":"Kerstin","familyName":"Berer","affiliation":["Max Planck Institute of Neurobiology"],"nameIdentifiers":[]},{"name":"Gerdes, Lisa Ann","nameType":"Personal","givenName":"Lisa Ann","familyName":"Gerdes","affiliation":["Ludwig-Maximilians-Universität München"],"nameIdentifiers":[]},{"name":"Cekanaviciute, Egle","nameType":"Personal","givenName":"Egle","familyName":"Cekanaviciute","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Jia, Sherman","nameType":"Personal","givenName":"Sherman","familyName":"Jia","affiliation":["University of California, San Francisco"],"nameIdentifiers":[]},{"name":"Xiao, Liang","nameType":"Personal","givenName":"Liang","familyName":"Xiao","affiliation":["BGI Group (China)"],"nameIdentifiers":[]},{"name":"Xia, Zhongkui","nameType":"Personal","givenName":"Zhongkui","familyName":"Xia","affiliation":["BGI Group (China)"],"nameIdentifiers":[]},{"name":"Liu, Chuan","nameType":"Personal","givenName":"Chuan","familyName":"Liu","affiliation":["BGI Group (China)"],"nameIdentifiers":[]},{"name":"Klotz, Luisa","nameType":"Personal","givenName":"Luisa","familyName":"Klotz","affiliation":["University Hospital Münster"],"nameIdentifiers":[]},{"name":"Stauffer, Uta","nameType":"Personal","givenName":"Uta","familyName":"Stauffer","affiliation":["Max Planck Institute of Immunobiology and Epigenetics"],"nameIdentifiers":[]},{"name":"Baranzini, Sergio","nameType":"Personal","givenName":"Sergio","familyName":"Baranzini","affiliation":[],"nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0003-0067-194X","nameIdentifierScheme":"ORCID"}]},{"name":"Kümpfel, Tania","nameType":"Personal","givenName":"Tania","familyName":"Kümpfel","affiliation":["Ludwig-Maximilians-Universität München"],"nameIdentifiers":[]},{"name":"Hohlfeld, Reinhard","nameType":"Personal","givenName":"Reinhard","familyName":"Hohlfeld","affiliation":["Ludwig-Maximilians-Universität München"],"nameIdentifiers":[]},{"name":"Krishnamoorthy, Gurumoorthy","nameType":"Personal","givenName":"Gurumoorthy","familyName":"Krishnamoorthy","affiliation":["Max Planck Institute of Neurobiology"],"nameIdentifiers":[]}],"titles":[{"title":"Gut Microbiota from Multiple Sclerosis patients triggers spontaneous autoimmune encephalomyelitis in mice --16S data--"}],"publisher":"Dryad","container":{},"publicationYear":2017,"subjects":[{"subject":"Multiple sclerosis","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"},{"subject":"Twins","schemeUri":"https://github.com/PLOS/plos-thesaurus","subjectScheme":"PLOS Subject Area Thesaurus"}],"contributors":[],"dates":[{"date":"2017-10-02T07:00:00Z","dateType":"Issued"},{"date":"2017-10-02T07:00:00Z","dateType":"Available"}],"language":"en","types":{"ris":"DATA","bibtex":"misc","citeproc":"dataset","schemaOrg":"Dataset","resourceType":"dataset","resourceTypeGeneral":"Dataset"},"relatedIdentifiers":[{"relationType":"IsCitedBy","relatedIdentifier":"10.1073/pnas.1711233114","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":["5168709 bytes"],"formats":[],"version":"2","rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The commensal microbiota has emerged as a key factor influencing human\n health and has been associated with several diseases, including those of\n the central nervous system (CNS). To investigate the role of the\n microbiome in multiple sclerosis (MS), a complex autoimmune disorder\n shaped by a multitude of genetic and environmental factors, we recruited a\n cohort of 34 monozygotic twin pairs discordant for MS, and compared their\n gut microbial composition by 16S ribosomal RNA sequencing of stool\n samples. While no major differences in the microbial profiles between\n MS-affected twins and their healthy co-twins were detected, a significant\n increase in some taxa (including Akkermansia) was seen in affected\n untreated subjects. To search for possible functional differences, we used\n a transgenic mouse model, in which spontaneous anti-CNS autoimmunity is\n dependent on the commensal gut flora. Germ-free mice colonized with\n microbiota from MS-affected twins, developed the MS-like disease with a\n significantly higher incidence than mice colonized with healthy\n twin-derived microbiota. Although alpha diversity was reduced compared to\n human donors, the microbial profiles of the colonized mice showed high\n intraindividual, remarkable temporal stability and a high transfer rate,.\n Analysis of the transplanted mouse microbiome at the level of individual\n taxa revealed several differences, including a significantly reduced\n abundance of the potentially autoimmune-protective genus Sutterella in\n mice colonized with MS-twin-derived microbiota. These findings provide\n first evidence that MS-derived microbiota contain factors that precipitate\n an MS-like autoimmune disease in a transgenic mouse model. This model\n lends itself to identify protective and pathogenic microbial component in\n human MS.","descriptionType":"Abstract"},{"description":"Study design. MZ twins were recruited by\n launching a national televised appeal as well as internet notification in\n Germany with support from the German Multiple Sclerosis Society (DMSG).\n Inclusion criteria for study participation were met for MZ twins with an\n MS diagnosis according to the revised McDonald criteria or clinically\n isolated syndrome (CIS) in one twin only. Exclusion criteria were\n antibiotic, glucocorticosteroidal or immunosuppressive treatment,\n gastrointestinal infection or diet irregularities in the 3 months prior to\n study entry. In total, 34 pairs (see Table 1) visited the outpatient\n department at the Institute of Clinical Neuroimmunology in Munich for a\n detailed interview on past and present medical, family and social history,\n a neurological examination as well as a nutrition questionnaire. To\n confirm the MS diagnosis, medical records including MRI scans were\n obtained and reviewed. Fecal samples were either directly collected in\n hospital or taken at home, stored at -20°C and transferred to the hospital\n in cooling bags. Finally, all samples were stored at -80°C. Of all\n participants buccal swabs for zygosity testing were taken. The study was\n approved by the local Ethics Committee of the Ludwig-Maximilians\n University Munich and all participants gave written informed consent.\n 16S rRNA Sequencing and Analysis.The\n V3-V5 region of bacterial 16S rRNA gene was amplified using the universal\n forward (5’-CCGTCAATTCMTTTGAGTTT-3’) and reverse primer (5’-ACTCCTA\n CGGGAGGCAGCAG-3’) incorporating the FLX Titanium adapters and a unique\n barcode sequence. PCR products were sequenced on a 454 GS FLX titanium\n pyrosequencer (454 Life Sciences, Branford, CT, USA) at BGI-Shenzhen.\n Analysis was performed using QIIME v1.9 as described (1). Essentially,\n amplicon sequences were quality-filtered and grouped to operational\n taxonomic units (OTUs) using SortMeRNA method (2) using GreenGenes version\n 13.8 97% dataset for closed reference. Sequences that did not match\n reference sequences in the GreenGenes database were dropped from the\n analysis. Taxonomy was assigned to the retained OTUs based on the\n GreenGenes reference sequence and the GreenGenes tree was used for all\n downstream phylogenetic community comparisons. Samples were filtered to at\n least 10000 sequences per sample and OTUs were filtered to retain only\n OTUs present in at least 5% of samples, covering at least 0.01% of total\n reads. After filtering, human samples were rarefied to 10975 sequences,\n while mouse samples were rarefied to 8137 sequences per sample, which were\n the lowest number of sequences per sample, respectively. For comparison\n between human and mouse samples, the human and mouse datasets were\n combined before OTU filtering and rarefaction. The resulting OTUs were\n filtered as described above and samples were rarefied to 6200 sequences\n per sample. Alpha diversity was calculated using phylogenetic diversity\n index method (3). For analysis of beta diversity, pairwise distance\n matrices were generated by phylogenetic metric of weighted UniFrac (4) and\n used for PCoA. For comparison of individual taxa, samples were not\n rarefied. Instead, OTU abundances were normalized using\n variance-stabilizing transformation and taxa distributions were compared\n using the Wald negative binomial test from the R software package DESeq2\n (as described in (4, 5) with Benjamini-Hochberg correction for multiple\n comparisons. All statistical analyses of differences between individual\n bacterial species were performed using QIIME v.1.9 or R (packages DESeq2\n and phyloseq).","descriptionType":"Methods"},{"description":"Two files are uploaded. The dataset contains both human and mice\n samples. Max_Planck_Twin_metadata.txt: Contains the\n sample metadataMax_Planck_Twin_OTU_table.txt: contains\n the normalized OTU abundances for each individualOTU\n abundances were normalized using variance-stabilizing transformation and\n taxa distributions were compared using the Wald negative binomial test\n from the R software package DESeq2 (as described in (4, 5) with\n Benjamini-Hochberg correction for multiple comparisons.","descriptionType":"Other"}],"geoLocations":[{"geoLocationBox":{"eastBoundLongitude":15.04149,"northBoundLatitude":55.057375,"southBoundLatitude":47.270352,"westBoundLongitude":5.866003},"geoLocationPlace":"Germany","geoLocationPoint":{"pointLatitude":51.196755,"pointLongitude":9.62743}},{"geoLocationBox":{"eastBoundLongitude":-122.35698,"northBoundLatitude":37.83239,"southBoundLatitude":37.70808,"westBoundLongitude":-122.51489},"geoLocationPlace":"San Francisco, CA, USA","geoLocationPoint":{"pointLatitude":37.778008,"pointLongitude":-122.431272}},{"geoLocationPlace":"New York, USA","geoLocationPoint":{"pointLatitude":43.00035,"pointLongitude":-75.4999}}],"fundingReferences":[{"schemeUri":"https://ror.org","funderName":"Max Planck Society","awardNumber":"SFB TR-128","funderIdentifier":"https://ror.org/01hhn8329","funderIdentifierType":"ROR"},{"funderName":"German Competence Network on Multiple Sclerosis"},{"schemeUri":"https://ror.org","funderName":"Max Planck Society","funderIdentifier":"https://ror.org/01hhn8329","funderIdentifierType":"ROR"}],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <creators>
    <creator>
      <creatorName nameType="Personal">Wekerle, Hartmut</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03ap2av50" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Max Planck Institute of Neurobiology</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Berer, Kerstin</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03ap2av50" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Max Planck Institute of Neurobiology</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Gerdes, Lisa Ann</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05591te55" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Ludwig-Maximilians-Universität München</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Cekanaviciute, Egle</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Jia, Sherman</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/043mz5j54" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University of California, San Francisco</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Xiao, Liang</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/045pn2j94" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">BGI Group (China)</affiliation>
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    <creator>
      <creatorName nameType="Personal">Xia, Zhongkui</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/045pn2j94" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">BGI Group (China)</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Liu, Chuan</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/045pn2j94" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">BGI Group (China)</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Klotz, Luisa</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/01856cw59" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">University Hospital Münster</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Stauffer, Uta</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/058xzat49" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Max Planck Institute of Immunobiology and Epigenetics</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Baranzini, Sergio</creatorName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="http://orcid.org/">0000-0003-0067-194X</nameIdentifier>
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    <creator>
      <creatorName nameType="Personal">Kümpfel, Tania</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05591te55" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Ludwig-Maximilians-Universität München</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Hohlfeld, Reinhard</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/05591te55" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Ludwig-Maximilians-Universität München</affiliation>
    </creator>
    <creator>
      <creatorName nameType="Personal">Krishnamoorthy, Gurumoorthy</creatorName>
      <affiliation affiliationIdentifier="https://ror.org/03ap2av50" affiliationIdentifierScheme="ROR" schemeURI="https://ror.org">Max Planck Institute of Neurobiology</affiliation>
    </creator>
  </creators>
  <titles>
    <title>
      Gut Microbiota from Multiple Sclerosis patients triggers spontaneous
      autoimmune encephalomyelitis in mice --16S data--
    </title>
  </titles>
  <publisher publisherIdentifier="https://ror.org/00x6h5n95" publisherIdentifierScheme="ROR" schemeURI="https://ror.org/">Dryad</publisher>
  <resourceType resourceTypeGeneral="Dataset">dataset</resourceType>
  <publicationYear>2017</publicationYear>
  <subjects>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Multiple sclerosis</subject>
    <subject subjectScheme="PLOS Subject Area Thesaurus" schemeURI="https://github.com/PLOS/plos-thesaurus">Twins</subject>
  </subjects>
  <fundingReferences>
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      <funderName>Max Planck Society</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01hhn8329</funderIdentifier>
      <awardNumber>SFB TR-128</awardNumber>
    </fundingReference>
    <fundingReference>
      <funderName>German Competence Network on Multiple Sclerosis</funderName>
    </fundingReference>
    <fundingReference>
      <funderName>Max Planck Society</funderName>
      <funderIdentifier funderIdentifierType="ROR">https://ror.org/01hhn8329</funderIdentifier>
    </fundingReference>
  </fundingReferences>
  <dates>
    <date dateType="Issued">2017-10-02T07:00:00Z</date>
    <date dateType="Available">2017-10-02T07:00:00Z</date>
  </dates>
  <language>en</language>
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    <description descriptionType="Abstract">
      The commensal microbiota has emerged as a key factor influencing human
      health and has been associated with several diseases, including those of
      the central nervous system (CNS). To investigate the role of the
      microbiome in multiple sclerosis (MS), a complex autoimmune disorder
      shaped by a multitude of genetic and environmental factors, we recruited a
      cohort of 34 monozygotic twin pairs discordant for MS, and compared their
      gut microbial composition by 16S ribosomal RNA sequencing of stool
      samples. While no major differences in the microbial profiles between
      MS-affected twins and their healthy co-twins were detected, a significant
      increase in some taxa (including Akkermansia) was seen in affected
      untreated subjects. To search for possible functional differences, we used
      a transgenic mouse model, in which spontaneous anti-CNS autoimmunity is
      dependent on the commensal gut flora. Germ-free mice colonized with
      microbiota from MS-affected twins, developed the MS-like disease with a
      significantly higher incidence than mice colonized with healthy
      twin-derived microbiota. Although alpha diversity was reduced compared to
      human donors, the microbial profiles of the colonized mice showed high
      intraindividual, remarkable temporal stability and a high transfer rate,.
      Analysis of the transplanted mouse microbiome at the level of individual
      taxa revealed several differences, including a significantly reduced
      abundance of the potentially autoimmune-protective genus Sutterella in
      mice colonized with MS-twin-derived microbiota. These findings provide
      first evidence that MS-derived microbiota contain factors that precipitate
      an MS-like autoimmune disease in a transgenic mouse model. This model
      lends itself to identify protective and pathogenic microbial component in
      human MS.
    </description>
    <description descriptionType="Methods">
      &lt;p&gt;Study design. &lt;/p&gt;&lt;p&gt;MZ twins were recruited by
      launching a national televised appeal as well as internet notification in
      Germany with support from the German Multiple Sclerosis Society (DMSG).
      Inclusion criteria for study participation were met for MZ twins with an
      MS diagnosis according to the revised McDonald criteria or clinically
      isolated syndrome (CIS) in one twin only. Exclusion criteria were
      antibiotic, glucocorticosteroidal or immunosuppressive treatment,
      gastrointestinal infection or diet irregularities in the 3 months prior to
      study entry. In total, 34 pairs (see Table 1) visited the outpatient
      department at the Institute of Clinical Neuroimmunology in Munich for a
      detailed interview on past and present medical, family and social history,
      a neurological examination as well as a nutrition questionnaire. To
      confirm the MS diagnosis, medical records including MRI scans were
      obtained and reviewed. Fecal samples were either directly collected in
      hospital or taken at home, stored at -20°C and transferred to the hospital
      in cooling bags. Finally, all samples were stored at -80°C. Of all
      participants buccal swabs for zygosity testing were taken. The study was
      approved by the local Ethics Committee of the Ludwig-Maximilians
      University Munich and all participants gave written informed consent.
      &lt;/p&gt;&lt;p&gt;16S rRNA Sequencing and Analysis.&lt;/p&gt;&lt;p&gt;The
      V3-V5 region of bacterial 16S rRNA gene was amplified using the universal
      forward (5’-CCGTCAATTCMTTTGAGTTT-3’) and reverse primer (5’-ACTCCTA
      CGGGAGGCAGCAG-3’) incorporating the FLX Titanium adapters and a unique
      barcode sequence. PCR products were sequenced on a 454 GS FLX titanium
      pyrosequencer (454 Life Sciences, Branford, CT, USA) at BGI-Shenzhen.
      Analysis was performed using QIIME v1.9 as described (1). Essentially,
      amplicon sequences were quality-filtered and grouped to operational
      taxonomic units (OTUs) using SortMeRNA method (2) using GreenGenes version
      13.8 97% dataset for closed reference. Sequences that did not match
      reference sequences in the GreenGenes database were dropped from the
      analysis. Taxonomy was assigned to the retained OTUs based on the
      GreenGenes reference sequence and the GreenGenes tree was used for all
      downstream phylogenetic community comparisons. Samples were filtered to at
      least 10000 sequences per sample and OTUs were filtered to retain only
      OTUs present in at least 5% of samples, covering at least 0.01% of total
      reads. After filtering, human samples were rarefied to 10975 sequences,
      while mouse samples were rarefied to 8137 sequences per sample, which were
      the lowest number of sequences per sample, respectively. For comparison
      between human and mouse samples, the human and mouse datasets were
      combined before OTU filtering and rarefaction. The resulting OTUs were
      filtered as described above and samples were rarefied to 6200 sequences
      per sample. Alpha diversity was calculated using phylogenetic diversity
      index method (3). For analysis of beta diversity, pairwise distance
      matrices were generated by phylogenetic metric of weighted UniFrac (4) and
      used for PCoA. For comparison of individual taxa, samples were not
      rarefied. Instead, OTU abundances were normalized using
      variance-stabilizing transformation and taxa distributions were compared
      using the Wald negative binomial test from the R software package DESeq2
      (as described in (4, 5) with Benjamini-Hochberg correction for multiple
      comparisons. All statistical analyses of differences between individual
      bacterial species were performed using QIIME v.1.9 or R (packages DESeq2
      and phyloseq). &lt;/p&gt;
    </description>
    <description descriptionType="Other">
      &lt;p&gt;Two files are uploaded. The dataset contains both human and mice
      samples. &lt;/p&gt;&lt;p&gt;Max_Planck_Twin_metadata.txt: Contains the
      sample metadata&lt;/p&gt;&lt;p&gt;Max_Planck_Twin_OTU_table.txt: contains
      the normalized OTU abundances for each individual&lt;/p&gt;&lt;p&gt;OTU
      abundances were normalized using variance-stabilizing transformation and
      taxa distributions were compared using the Wald negative binomial test
      from the R software package DESeq2 (as described in (4, 5) with
      Benjamini-Hochberg correction for multiple comparisons.&lt;/p&gt;
    </description>
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