{"data":{"id":"10.6084/m9.figshare.c.6032487.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.6032487.v1","prefix":"10.6084","suffix":"m9.figshare.c.6032487.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Safa, Babak N.","givenName":"Babak N.","familyName":"Safa","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-1849-2870","nameIdentifierScheme":"ORCID"}],"affiliation":[]},{"name":"Bahrani Fard, Mohammad Reza","givenName":"Mohammad Reza","familyName":"Bahrani Fard","affiliation":[],"nameIdentifiers":[]},{"name":"Ethier, C. Ross","givenName":"C. Ross","familyName":"Ethier","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Supplementary material from \"\u003ci\u003eIn vivo\u003c/i\u003e biomechanical assessment of iridial deformations and muscle contractions in human eyes\""}],"publisher":"The Royal Society","container":{},"publicationYear":2022,"subjects":[{"subject":"Biological Engineering"},{"subject":"110601 Biomechanics","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"111602 Human Biophysics","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"80109 Pattern Recognition and Data Mining","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Computer and information sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2022-06-06","dateType":"Created"},{"date":"2022-06-06","dateType":"Updated"},{"date":"2022","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1098/rsif.2022.0108","relatedIdentifierType":"DOI"},{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.6032487","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"The iris is a muscular organ whose deformations can cause primary angle-closure glaucoma (PACG), a leading cause of blindness. PACG risk assessment does not consider iridial biomechanical factors, despite their expected influence on iris deformations. Here, we exploited an existing biometric dataset consisting of near-infrared movies acquired during the pupillary light reflex (PLR) as a unique resource to study iris biomechanics. The PLR caused significant (greater than 100%) and essentially spatially uniform radial strains in the iris \u003ci\u003ein vivo\u003c/i\u003e, consistent with previous findings. Inverse finite-element modelling showed that sphincter muscle tractions were \u003ci\u003eca\u003c/i\u003e fivefold greater than iridial stroma stiffness (range 4- to 13-fold, depending on sphincter muscle size). This muscle traction is greater than has been previously estimated, which may be due to methodological differences and/or to different patient populations in our study (European descent) versus previous studies (Asian); the latter possibility is of particular interest due to differential incidence rates of PACG in these populations. Our methodology is fast and inexpensive and may be a useful tool in understanding biomechanical factors contributing to PACG.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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