{"data":{"id":"10.6084/m9.figshare.c.5793482","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.5793482","prefix":"10.6084","suffix":"m9.figshare.c.5793482","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Reichel, Felix","givenName":"Felix","familyName":"Reichel","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0001-5354-865X","nameIdentifierScheme":"ORCID"}],"affiliation":[]},{"name":"Kräter, Martin","givenName":"Martin","familyName":"Kräter","affiliation":[],"nameIdentifiers":[]},{"name":"Peikert, Kevin","givenName":"Kevin","familyName":"Peikert","affiliation":[],"nameIdentifiers":[]},{"name":"Glaß, Hannes","givenName":"Hannes","familyName":"Glaß","affiliation":[],"nameIdentifiers":[]},{"name":"Rosendahl, Philipp","givenName":"Philipp","familyName":"Rosendahl","nameIdentifiers":[{"schemeUri":"https://orcid.org","nameIdentifier":"https://orcid.org/0000-0002-9545-5045","nameIdentifierScheme":"ORCID"}],"affiliation":[]},{"name":"Herbig, Maik","givenName":"Maik","familyName":"Herbig","affiliation":[],"nameIdentifiers":[]},{"name":"Rivera Prieto, Alejandro","givenName":"Alejandro","familyName":"Rivera Prieto","affiliation":[],"nameIdentifiers":[]},{"name":"Kihm, Alexander","givenName":"Alexander","familyName":"Kihm","affiliation":[],"nameIdentifiers":[]},{"name":"Bosman, Giel","givenName":"Giel","familyName":"Bosman","affiliation":[],"nameIdentifiers":[]},{"name":"Kaestner, Lars","givenName":"Lars","familyName":"Kaestner","affiliation":[],"nameIdentifiers":[]},{"name":"Hermann, Andreas","givenName":"Andreas","familyName":"Hermann","affiliation":[],"nameIdentifiers":[]},{"name":"Guck, Jochen","givenName":"Jochen","familyName":"Guck","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium"}],"publisher":"figshare","container":{},"publicationYear":2022,"subjects":[{"subject":"29901 Biological Physics","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"110904 Neurology and Neuromuscular Diseases","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biophysics"},{"subject":"111602 Human Biophysics","schemeUri":"http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E","subjectScheme":"FOR"},{"subject":"FOS: Basic medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2022-01-24","dateType":"Created"},{"date":"2022-03-15","dateType":"Updated"},{"date":"2022","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"This collection contains results supporting findings presented in the following manuscript:\u003cbr\u003eReichel et al., 2022, Frontiers in Physiology\u003cbr\u003e\u003cb\u003eChanges in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium\u003c/b\u003e\u003cbr\u003e\u003cb\u003e\u003cbr\u003e\u003c/b\u003ehttps://www.frontiersin.org/articles/10.3389/fphys.2022.852946\u003cbr\u003e\u003cb\u003eAbstract\u003c/b\u003eMisshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder. The altered RBC morphology likely influences their biomechanical properties which are crucial for the cells to pass the microvasculature. Here, we investigated blood cell deformability of 5 ChAc patients compared to healthy controls during up to one-year individual off-label treatment with the tyrosine kinases inhibitor dasatinib or several weeks with lithium. Measurements with two microfluidic techniques allowed us to assess RBC deformability under different shear stresses. Furthermore, we characterized leukocyte stiffness at high shear stresses. The results show that blood cell deformability – including both RBCs and leukocytes - in general is altered in ChAc patients compared to healthy donors. Therefore, this study shows for the first time an impairment of leukocyte properties in ChAc. During treatment with dasatinib or lithium, we observe alterations in RBC deformability and a stiffness increase for leukocytes. The hematological phenotype of ChAc patients hints at a reorganization of the cytoskeleton in blood cells which partly explains the altered mechanical properties observed here. These findings highlight the need for a systematic assessment of the contribution of impaired blood cell mechanics to the clinical manifestation of ChAc.\u003cbr\u003eAnalysis files and creation of figure plots are documented here.\u003cbr\u003e\u003cb\u003eDatasets for raw data from shape analysis experiments:\u003c/b\u003e\u003cb\u003e\u003cbr\u003e\u003c/b\u003eDatasets for these experiments were compressed into several 20GB archives sorted for each patient. To unpack the data, you need to download the dataset for every patient. The raw data can be analyzed with the scripts `Cell_tracking_new.py` to get the individual cell tracks and the shape selection was done with the script `shape_selector_Ac.py` that are found in the folder of every experiment.\u003cb\u003e\u003cbr\u003e\u003c/b\u003e\u003cb\u003ePatient 1:\u003c/b\u003eChAc shape_analysis_P1.zip.001 - .006 \u003cb\u003e\u003cbr\u003e\u003c/b\u003e\u003cbr\u003e\u003cb\u003ePatient 2:\u003c/b\u003eChAc shape_analysis_P2.zip.001 - .006 \u003cbr\u003e\u003cb\u003ePatient 3:\u003c/b\u003eChAc shape_analysis_P3.zip.001 - .005\u003cbr\u003e\u003cb\u003ePatient 4:\u003c/b\u003eChAc shape_analysis_P4.zip.001 + .002 \u003cbr\u003e\u003cb\u003ePatient 5:\u003c/b\u003eChAc shape_analysis_P5.zip.001 + .002\u003cbr\u003e\u003cbr\u003e\u003cb\u003eRT-fDC on red blood cells\u003c/b\u003e\u003cbr\u003eDatasets for experiment raw dat for all patients:10.6084/m9.figshare.18622520 + 10.6084/m9.figshare.18624518\u003cbr\u003e\u003cbr\u003e\u003cb\u003eRT-fDC on white blood cells:\u003c/b\u003e10.6084/m9.figshare.18598397\u003cbr\u003e","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"<?xml version="1.0" encoding="UTF-8"?>
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  <identifier identifierType="DOI">10.6084/M9.FIGSHARE.C.5793482</identifier>
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    <creator>
      <creatorName>Felix Reichel</creatorName>
      <givenName>Felix</givenName>
      <familyName>Reichel</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org">0000-0001-5354-865X</nameIdentifier>
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    <creator>
      <creatorName>Martin Kräter</creatorName>
      <givenName>Martin</givenName>
      <familyName>Kräter</familyName>
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    <creator>
      <creatorName>Kevin Peikert</creatorName>
      <givenName>Kevin</givenName>
      <familyName>Peikert</familyName>
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    <creator>
      <creatorName>Hannes Glaß</creatorName>
      <givenName>Hannes</givenName>
      <familyName>Glaß</familyName>
    </creator>
    <creator>
      <creatorName>Philipp Rosendahl</creatorName>
      <givenName>Philipp</givenName>
      <familyName>Rosendahl</familyName>
      <nameIdentifier nameIdentifierScheme="ORCID" schemeURI="https://orcid.org">0000-0002-9545-5045</nameIdentifier>
    </creator>
    <creator>
      <creatorName>Maik Herbig</creatorName>
      <givenName>Maik</givenName>
      <familyName>Herbig</familyName>
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    <creator>
      <creatorName>Alejandro Rivera Prieto</creatorName>
      <givenName>Alejandro</givenName>
      <familyName>Rivera Prieto</familyName>
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      <creatorName>Alexander Kihm</creatorName>
      <givenName>Alexander</givenName>
      <familyName>Kihm</familyName>
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    <creator>
      <creatorName>Giel Bosman</creatorName>
      <givenName>Giel</givenName>
      <familyName>Bosman</familyName>
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    <creator>
      <creatorName>Lars Kaestner</creatorName>
      <givenName>Lars</givenName>
      <familyName>Kaestner</familyName>
    </creator>
    <creator>
      <creatorName>Andreas Hermann</creatorName>
      <givenName>Andreas</givenName>
      <familyName>Hermann</familyName>
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    <creator>
      <creatorName>Jochen Guck</creatorName>
      <givenName>Jochen</givenName>
      <familyName>Guck</familyName>
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  <titles>
    <title>Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium</title>
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  <descriptions>
    <description descriptionType="Abstract">This collection contains results supporting findings presented in the following manuscript:&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;Reichel et al., 2022, Frontiers in Physiology&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;Changes in blood cell deformability in Chorea-Acanthocytosis and effects of treatment with dasatinib or lithium&lt;/b&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;&lt;br&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;&lt;a href="https://www.frontiersin.org/articles/10.3389/fphys.2022.852946" rel="noopener noreferrer" target="_blank"&gt;https://www.frontiersin.org/articles/10.3389/fphys.2022.852946&lt;/a&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;&lt;b&gt;Abstract&lt;/b&gt;&lt;/div&gt;&lt;div&gt;Misshaped red blood cells (RBCs), characterized by thorn-like protrusions known as acanthocytes, are a key diagnostic feature in Chorea-Acanthocytosis (ChAc), a rare neurodegenerative disorder. The altered RBC morphology likely influences their biomechanical properties which are crucial for the cells to pass the microvasculature. Here, we investigated blood cell deformability of 5 ChAc patients compared to healthy controls during up to one-year individual off-label treatment with the tyrosine kinases inhibitor dasatinib or several weeks with lithium. Measurements with two microfluidic techniques allowed us to assess RBC deformability under different shear stresses. Furthermore, we characterized leukocyte stiffness at high shear stresses. The results show that blood cell deformability – including both RBCs and leukocytes - in general is altered in ChAc patients compared to healthy donors. Therefore, this study shows for the first time an impairment of leukocyte properties in ChAc. During treatment with dasatinib or lithium, we observe alterations in RBC deformability and a stiffness increase for leukocytes. The hematological phenotype of ChAc patients hints at a reorganization of the cytoskeleton in blood cells which partly explains the altered mechanical properties observed here. These findings highlight the need for a systematic assessment of the contribution of impaired blood cell mechanics to the clinical manifestation of ChAc.&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;Analysis files and creation of figure plots are documented &lt;a href="https://gitlab.gwdg.de/freiche/changes-in-blood-cell-deformability-in-chorea-acanthocytosis-and-effects-of-treatment-with-dasatinib-or-lithium" rel="noopener noreferrer" target="_blank"&gt;here&lt;/a&gt;.&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;&lt;u&gt;Datasets for raw data from shape analysis experiments:&lt;/u&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;&lt;u&gt;&lt;br&gt;&lt;/u&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;Datasets for these experiments were compressed into several 20GB archives sorted for each patient. To unpack the data, you need to download the dataset for every patient. The raw data can be analyzed with the scripts `Cell_tracking_new.py` to get the individual cell tracks  and the shape selection was done with the script `shape_selector_Ac.py` that are found in the folder of every experiment.&lt;/div&gt;&lt;div&gt;&lt;b&gt;&lt;u&gt;&lt;br&gt;&lt;/u&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;Patient 1:&lt;/b&gt;&lt;/div&gt;&lt;div&gt;ChAc shape_analysis_P1.zip.001 - .006 &lt;b&gt;&lt;br&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;&lt;b&gt;Patient 2:&lt;/b&gt;&lt;/div&gt;&lt;div&gt;ChAc shape_analysis_P2.zip.001 - .006 &lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;&lt;b&gt;Patient 3:&lt;/b&gt;&lt;/div&gt;&lt;div&gt;ChAc shape_analysis_P3.zip.001 - .005&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;&lt;b&gt;Patient 4:&lt;/b&gt;&lt;/div&gt;&lt;div&gt;ChAc shape_analysis_P4.zip.001 + .002 &lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;div&gt;&lt;b&gt;Patient 5:&lt;/b&gt;&lt;/div&gt;&lt;div&gt;ChAc shape_analysis_P5.zip.001 + .002&lt;/div&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;&lt;u&gt;RT-fDC on red blood cells&lt;/u&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;Datasets for experiment raw dat for all patients:&lt;/div&gt;&lt;div&gt;&lt;a href="https://doi.org/10.6084/m9.figshare.18622520" rel="noreferrer noopener" target="_blank"&gt;10.6084/m9.figshare.18622520&lt;/a&gt; + &lt;a href="https://doi.org/10.6084/m9.figshare.18624518" rel="noreferrer noopener" target="_blank"&gt;10.6084/m9.figshare.18624518&lt;/a&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;br&gt;&lt;/div&gt;&lt;div&gt;&lt;b&gt;&lt;u&gt;RT-fDC on white blood cells:&lt;/u&gt;&lt;/b&gt;&lt;/div&gt;&lt;div&gt;&lt;a href="https://doi.org/10.6084/m9.figshare.18598397" rel="noreferrer noopener" target="_blank"&gt;10.6084/m9.figshare.18598397&lt;/a&gt;&lt;br&gt;&lt;/div&gt;</description>
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    <subject schemeURI="http://www.abs.gov.au/ausstats/abs@.nsf/0/6BB427AB9696C225CA2574180004463E" subjectScheme="FOR">111602 Human Biophysics</subject>
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