{"data":{"id":"10.6084/m9.figshare.c.4150538","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.4150538","prefix":"10.6084","suffix":"m9.figshare.c.4150538","identifiers":[{"identifier":"https://doi.org/10.6084/m9.figshare.c.4150538","identifierType":"DOI"}],"alternateIdentifiers":[{"alternateIdentifierType":"DOI","alternateIdentifier":"https://doi.org/10.6084/m9.figshare.c.4150538"}],"creators":[{"name":"KEYVAN JAFERZADEH","affiliation":[],"nameIdentifiers":[]},{"name":"Inkyu Moon","affiliation":[],"nameIdentifiers":[]},{"name":"MANON BARDYN","affiliation":[],"nameIdentifiers":[]},{"name":"MICHEL PRUDENT","affiliation":[],"nameIdentifiers":[]},{"name":"JEAN-DANIEL TISSOT","affiliation":[],"nameIdentifiers":[]},{"name":"Rappaz, Benjamin","nameType":"Personal","givenName":"Benjamin","familyName":"Rappaz","affiliation":[],"nameIdentifiers":[]},{"name":"Javidi, Bahram","nameType":"Personal","givenName":"Bahram","familyName":"Javidi","affiliation":[],"nameIdentifiers":[]},{"name":"Turcatti, Gerardo","nameType":"Personal","givenName":"Gerardo","familyName":"Turcatti","affiliation":[],"nameIdentifiers":[]},{"name":"Marquet, Pierre","nameType":"Personal","givenName":"Pierre","familyName":"Marquet","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Quantification of stored red blood cells fluctuations by time-lapse holographic cell imaging"}],"publisher":"Figshare","container":{},"publicationYear":2018,"subjects":[{"subject":"111302 Optical Technology","subjectScheme":"FOR"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"91302 Automation and Control Engineering","subjectScheme":"FOR"},{"subject":"FOS: Electrical engineering, electronic engineering, information engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"80106 Image Processing","subjectScheme":"FOR"},{"subject":"FOS: Computer and information sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Artificial Intelligence and Image Processing"},{"subject":"Computer Engineering"},{"subject":"90699 Electrical and Electronic Engineering not elsewhere classified","subjectScheme":"FOR"},{"subject":"90399 Biomedical Engineering not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Medical engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Structural Biology"}],"contributors":[],"dates":[{"date":"2018-07-01","dateType":"Created"},{"date":"2018-09-10","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1364/boe.9.004714","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"The functionality of human red blood cells (RBCs) has clinical relevance for hematology and depends on RBC dynamics and morphology. We propose methods to quantitatively calculate fluctuations rate with nanometric axial and millisecond temporal sensitivity at the single-cell level by using time-lapse holographic cell imaging. For this quantitative analysis, cell membrane fluctuations (CMFs) were measured for RBCs stored at different storage times. Measurements were taken over the whole membrane for both the ring and dimple sections separately. The measurements show that healthy RBCs that maintain their discocyte shape become stiffer with storage time. The correlation analysis demonstrates a significant negative correlation between CMFs and the sphericity coefficient which characterizes the morphological type of erythrocyte. In addition, we show the correlation results between CMFs and other morphological properties such as projected surface area, surface area, mean corpuscular volume, and mean corpuscular hemoglobin.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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