{"data":{"id":"10.6084/m9.figshare.c.3950623","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.3950623","prefix":"10.6084","suffix":"m9.figshare.c.3950623","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Allen, Wes","nameType":"Personal","givenName":"Wes","familyName":"Allen","affiliation":[],"nameIdentifiers":[]},{"name":"Kennedy, Kelsey","nameType":"Personal","givenName":"Kelsey","familyName":"Kennedy","affiliation":[],"nameIdentifiers":[]},{"name":"Fang, Qi","nameType":"Personal","givenName":"Qi","familyName":"Fang","affiliation":[],"nameIdentifiers":[]},{"name":"Lixin Chin","affiliation":[],"nameIdentifiers":[]},{"name":"Curatolo, Andrea","nameType":"Personal","givenName":"Andrea","familyName":"Curatolo","affiliation":[],"nameIdentifiers":[]},{"name":"Zilkens, Renate","nameType":"Personal","givenName":"Renate","familyName":"Zilkens","affiliation":[],"nameIdentifiers":[]},{"name":"Synn Lynn Chin","affiliation":[],"nameIdentifiers":[]},{"name":"Dessauvagie, Benjamin","nameType":"Personal","givenName":"Benjamin","familyName":"Dessauvagie","affiliation":[],"nameIdentifiers":[]},{"name":"Latham, Bruce","nameType":"Personal","givenName":"Bruce","familyName":"Latham","affiliation":[],"nameIdentifiers":[]},{"name":"Christobel Saunders","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Wide-field quantitative micro-elastography of human breast tissue"}],"publisher":"Figshare","container":{},"publicationYear":2018,"subjects":[{"subject":"Cancer"},{"subject":"90606 Photonics and Electro-Optical Engineering (excl. Communications)","subjectScheme":"FOR"},{"subject":"FOS: Electrical engineering, electronic engineering, information engineering","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2017-12-11","dateType":"Created"},{"date":"2018-02-09","dateType":"Updated"},{"date":"2018","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1364/boe.9.001082","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC BY 4.0","rightsUri":"https://creativecommons.org/licenses/by/4.0"}],"descriptions":[{"description":"Currently, 20-30% of patients undergoing breast-conserving surgery require a second surgery due to insufficient surgical margins in the initial procedure. We have developed a wide-field quantitative micro-elastography system for the assessment of tumor margins. In this technique, we map tissue elasticity over a field-of-view of ~46 × 46 mm. We performed wide-field quantitative micro-elastography on thirteen specimens of freshly excised tissue acquired from patients undergoing mastectomy. We present wide-field optical coherence tomography (OCT) images, qualitative (strain) micro-elastograms and quantitative (elasticity) micro-elastograms, acquired in 10 minutes. We demonstrate, for the first time, that wide-field quantitative micro-elastography can extend the range of tumors visible using OCT-based elastography by providing contrast not present in either OCT or qualitative micro-elastography and, in addition, can reduce imaging artifacts caused by a lack of contact between tissue and the imaging window. Also, we describe how the combined evaluation of OCT, qualitative micro-elastograms and quantitative micro-elastograms can improve the visualization of tumor.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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