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As previous inhalation studies revealed considerable differences between surface functionalized NPs with respect to deposition and toxicity, our aim was to investigate the influence of lipid and/or protein binding on these processes. Thus, we analyzed a set of surface functionalized NPs including different SiO\u003csub\u003e2\u003c/sub\u003e and ZrO\u003csub\u003e2\u003c/sub\u003e in pure phospholipids, CuroSurf\u003csup\u003eTM\u003c/sup\u003e and purified native porcine pulmonary surfactant (nS). Lipid binding was surprisingly low for pure phospholipids and only few NPs attracted a minimal lipid corona. Additional presence of hydrophobic surfactant protein (SP) B in CuroSurf\u003csup\u003eTM\u003c/sup\u003e promoted lipid binding to NPs functionalized with Amino or PEG residues. The presence of the hydrophilic SP A in nS facilitated lipid binding to all NPs. 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    <title>Influence of agglomeration and specific lung lining lipid/protein interaction on short-term inhalation toxicity</title>
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    <description descriptionType="Abstract">Lung lining fluid is the first biological barrier nanoparticles (NPs) encounter during inhalation. As previous inhalation studies revealed considerable differences between surface functionalized NPs with respect to deposition and toxicity, our aim was to investigate the influence of lipid and/or protein binding on these processes. Thus, we analyzed a set of surface functionalized NPs including different SiO&lt;sub&gt;2&lt;/sub&gt; and ZrO&lt;sub&gt;2&lt;/sub&gt; in pure phospholipids, CuroSurf&lt;sup&gt;TM&lt;/sup&gt; and purified native porcine pulmonary surfactant (nS). Lipid binding was surprisingly low for pure phospholipids and only few NPs attracted a minimal lipid corona. Additional presence of hydrophobic surfactant protein (SP) B in CuroSurf&lt;sup&gt;TM&lt;/sup&gt; promoted lipid binding to NPs functionalized with Amino or PEG residues. The presence of the hydrophilic SP A in nS facilitated lipid binding to all NPs. In line with this the degree of lipid and protein affinities for different surface functionalized SiO&lt;sub&gt;2&lt;/sub&gt; NPs in nS followed the same order (SiO&lt;sub&gt;2&lt;/sub&gt; Phosphate ∼ unmodified SiO&lt;sub&gt;2&lt;/sub&gt; 2 PEG 2 Amino NPs). Agglomeration and biomolecule interaction of NPs in nS was mainly influenced by surface charge and hydrophobicity. Toxicological differences as observed in short-term inhalation studies (STIS) were mainly influenced by the core composition and/or surface reactivity of NPs. However, agglomeration in lipid media and lipid/protein affinity appeared to play a modulatory role on short-term inhalation toxicity. For instance, lipophilic NPs like ZrO&lt;sub&gt;2&lt;/sub&gt;, which are interacting with nS to a higher extent, exhibited a far higher lung burden than their hydrophilic counterparts, which deserves further attention to predict or model effects of respirable NPs.</description>
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