{"data":{"id":"10.6084/m9.figshare.c.3249328.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.3249328.v1","prefix":"10.6084","suffix":"m9.figshare.c.3249328.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Caglar, Sema","nameType":"Personal","givenName":"Sema","familyName":"Caglar","affiliation":[],"nameIdentifiers":[]},{"name":"Dilek, Esra","nameType":"Personal","givenName":"Esra","familyName":"Dilek","affiliation":[],"nameIdentifiers":[]},{"name":"Alisir, Sevim Hamamci","nameType":"Personal","givenName":"Sevim Hamamci","familyName":"Alisir","affiliation":[],"nameIdentifiers":[]},{"name":"Bulent Caglar","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"New copper(II) complexes including pyridine-2,5-dicarboxylic acid: Synthesis, spectroscopic, thermal properties, crystal structure and how these complexes interact with purified PON 1 enzyme"}],"publisher":"Figshare","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physiology"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Marine Biology"}],"contributors":[],"dates":[{"date":"2016-05-12","dateType":"Created"},{"date":"2016-05-12","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsSupplementTo","relatedIdentifier":"10.1080/00958972.2016.1188295","relatedIdentifierType":"DOI"},{"relationType":"IsPreviousVersionOf","relatedIdentifier":"10.6084/m9.figshare.c.3249328","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"We report the synthesis of two square-pyramidal copper(II) complexes, [Cu(2,5-pydc)(2-aepy)(H\u003csub\u003e2\u003c/sub\u003eO)]·H\u003csub\u003e2\u003c/sub\u003eO, \u003cb\u003e1\u003c/b\u003e, and [Cu(2,5-pydc)(2-ampy)(H\u003csub\u003e2\u003c/sub\u003eO)]·H\u003csub\u003e2\u003c/sub\u003eO, \u003cb\u003e2\u003c/b\u003e (2-aepy = 2-(aminoethyl)pyridine, 2-ampy = 2-(aminomethyl)pyridine, 2,5-pydc = pyridine-2,5-dicarboxylic acid or isocinchomeronic acid). The synthesized complexes have been characterized by X-ray diffraction, FT-IR, elemental and thermal analysis techniques. The crystal structure of \u003cb\u003e1\u003c/b\u003e was established by X-ray analysis. Powder X-ray diffraction analysis showed that the complexes are pure. The inhibition of human serum paraoxonase 1 (PON 1, EC 3.1.8.1) enzyme with these complexes were investigated. We used diethyl 4-nitrophenyl phosphate as a substrate to measure the paraoxonase activity of PON 1 enzyme spectrophotometrically. Complexes \u003cb\u003e1\u003c/b\u003e and \u003cb\u003e2\u003c/b\u003e decreased the \u003ci\u003ein vitro\u003c/i\u003e PON 1 activity with different inhibition mechanisms. Complexes \u003cb\u003e1\u003c/b\u003e and \u003cb\u003e2\u003c/b\u003e inhibited paraoxonase activity of this enzyme as competitively and uncompetitively, respectively.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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