{"data":{"id":"10.6084/m9.figshare.c.3213154.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.3213154.v1","prefix":"10.6084","suffix":"m9.figshare.c.3213154.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Fenghong Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Ng, Shu","nameType":"Personal","givenName":"Shu","familyName":"Ng","affiliation":[],"nameIdentifiers":[]},{"name":"Huguet, Florence","nameType":"Personal","givenName":"Florence","familyName":"Huguet","affiliation":[],"nameIdentifiers":[]},{"name":"Yorke, Ellen D.","nameType":"Personal","givenName":"Ellen D.","familyName":"Yorke","affiliation":[],"nameIdentifiers":[]},{"name":"Gikas S. Mageras","affiliation":[],"nameIdentifiers":[]},{"name":"Goodman, Karyn A.","nameType":"Personal","givenName":"Karyn A.","familyName":"Goodman","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Are fiducial markers useful surrogates when using respiratory gating to reduce motion of gastroesophageal junction tumors?"}],"publisher":"Figshare","container":{},"publicationYear":2016,"subjects":[{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Physiology"},{"subject":"Cancer"},{"subject":"Computational Biology"}],"contributors":[],"dates":[{"date":"2016-05-06","dateType":"Created"},{"date":"2016-05-06","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"\u003cb\u003eBackground:\u003c/b\u003e Radiation therapy (RT) is an integral component of the management of gastroesophageal junction (GEJ) tumors. We evaluated the use of implanted radiopaque fiducials as tumor surrogates to allow for more focal delivery of RT to these mobile tumors when using respiratory gating (RG) to reduce motion. \u003cb\u003eMaterial and methods:\u003c/b\u003e We analyzed four-dimensional computed tomography scans of 20 GEJ patients treated with RG and assessed correlation between tumor and implanted fiducial motion over the whole respiratory cycle and within a clinically realistic gate around end-exhalation. We evaluated fiducial motion concordance in 11 patients with multiple fiducials. \u003cb\u003eResults:\u003c/b\u003e Gating reduced anterior-posterior (AP) and superior-inferior (SI) mean tumor and fiducial motions by over 50%. Fiducials and primary tumor motions were moderately correlated: R\u003csup\u003e2\u003c/sup\u003e for AP and SI linear fits to the entire group were 0.54 and 0.68, respectively, but the correlation had strong inter-patient variation. For all patients with multiple fiducials, relative in-gate displacements were below 3 mm; results were similar for eight of 11 patients over the whole cycle. \u003cb\u003eConclusion:\u003c/b\u003e Implanted fiducial and gross tumor volume (GTV) motions correlate well but the correlation is patient-specific and may be dependent on the location of the fiducials with respect to the GTV.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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