{"data":{"id":"10.6084/m9.figshare.c.3211828","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.3211828","prefix":"10.6084","suffix":"m9.figshare.c.3211828","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"M. Saeed Abaee","affiliation":[],"nameIdentifiers":[]},{"name":"Soodabeh Forghani","affiliation":[],"nameIdentifiers":[]},{"name":"Mojtahedi, Mohammad M.","nameType":"Personal","givenName":"Mohammad M.","familyName":"Mojtahedi","affiliation":[],"nameIdentifiers":[]},{"name":"Harms, Klaus","nameType":"Personal","givenName":"Klaus","familyName":"Harms","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Facile one-pot synthesis of novel dicyanoanilines fused to tetrahydro-4\u003ci\u003eH\u003c/i\u003e-thiopyran-4-one ring via Et\u003csub\u003e3\u003c/sub\u003eN/H\u003csub\u003e2\u003c/sub\u003eO catalyzed pseudo four-component reaction"}],"publisher":"Figshare","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2016-05-06","dateType":"Created"},{"date":"2016-05-06","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"A facile procedure is developed for one-pot synthesis of a new group of dicyanoanilines. Tetrahydro-4H-thiopyran-4-one, \u003cb\u003e1\u003c/b\u003e, undergoes a pseudo four-component reaction with various aldehydes bearing different groups and two equivalents of malononitrile in aqueous media in the presence of triethylamine (Et\u003csub\u003e3\u003c/sub\u003eN). As a result, novel thiopyran-fused dicyanoanilines \u003cb\u003e4\u003c/b\u003e are formed efficiently in the reaction mixtures in 90–97% yield within 9–12 h mixing at 40°C. Due to the polarity of the medium, products precipitate in the mixture spontaneously allowing for easy purification by recrystallization avoiding cumbersome chromatographic separations. Characterization of the products was performed by spectroscopic methods and, in one case, was further supported by X-ray crystallographic experiments.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"PD94bWwgdmVyc2lvbj0iMS4wIiBlbmNvZGluZz0iVVRGLTgiPz4KPHJlc291cmNlIHhtbG5zOnhzaT0iaHR0cDovL3d3dy53My5vcmcvMjAwMS9YTUxTY2hlbWEtaW5zdGFuY2UiIHhtbG5zPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCIgeHNpOnNjaGVtYUxvY2F0aW9uPSJodHRwOi8vZGF0YWNpdGUub3JnL3NjaGVtYS9rZXJuZWwtNCBodHRwOi8vc2NoZW1hLmRhdGFjaXRlLm9yZy9tZXRhL2tlcm5lbC00L21ldGFkYXRhLnhzZCI+CiAgPGlkZW50aWZpZXIgaWRlbnRpZmllclR5cGU9IkRPSSI+MTAuNjA4NC9NOS5GSUdTSEFSRS5DLjMyMTE4Mjg8L2lkZW50aWZpZXI+CiAgPGNyZWF0b3JzPgogICAgPGNyZWF0b3I+CiAgICAgIDxjcmVhdG9yTmFtZT5NLiBTYWVlZCBBYmFlZTwvY3JlYXRvck5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lPlNvb2RhYmVoIEZvcmdoYW5pPC9jcmVhdG9yTmFtZT4KICAgIDwvY3JlYXRvcj4KICAgIDxjcmVhdG9yPgogICAgICA8Y3JlYXRvck5hbWUgbmFtZVR5cGU9IlBlcnNvbmFsIj5Nb2p0YWhlZGksIE1vaGFtbWFkIE0uPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5Nb2hhbW1hZCBNLjwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5Nb2p0YWhlZGk8L2ZhbWlseU5hbWU+CiAgICA8L2NyZWF0b3I+CiAgICA8Y3JlYXRvcj4KICAgICAgPGNyZWF0b3JOYW1lIG5hbWVUeXBlPSJQZXJzb25hbCI+SGFybXMsIEtsYXVzPC9jcmVhdG9yTmFtZT4KICAgICAgPGdpdmVuTmFtZT5LbGF1czwvZ2l2ZW5OYW1lPgogICAgICA8ZmFtaWx5TmFtZT5IYXJtczwvZmFtaWx5TmFtZT4KICAgIDwvY3JlYXRvcj4KICA8L2NyZWF0b3JzPgogIDx0aXRsZXM+CiAgICA8dGl0bGU+RmFjaWxlIG9uZS1wb3Qgc3ludGhlc2lzIG9mIG5vdmVsIGRpY3lhbm9hbmlsaW5lcyBmdXNlZCB0byB0ZXRyYWh5ZHJvLTQmbHQ7aSZndDtIJmx0Oy9pJmd0Oy10aGlvcHlyYW4tNC1vbmUgcmluZyB2aWEgRXQmbHQ7c3ViJmd0OzMmbHQ7L3N1YiZndDtOL0gmbHQ7c3ViJmd0OzImbHQ7L3N1YiZndDtPIGNhdGFseXplZCBwc2V1ZG8gZm91ci1jb21wb25lbnQgcmVhY3Rpb248L3RpdGxlPgogIDwvdGl0bGVzPgogIDxwdWJsaXNoZXI+Rmlnc2hhcmU8L3B1Ymxpc2hlcj4KICA8cHVibGljYXRpb25ZZWFyPjIwMTY8L3B1YmxpY2F0aW9uWWVhcj4KICA8cmVzb3VyY2VUeXBlIHJlc291cmNlVHlwZUdlbmVyYWw9IkNvbGxlY3Rpb24iPkNvbGxlY3Rpb248L3Jlc291cmNlVHlwZT4KICA8c3ViamVjdHM+CiAgICA8c3ViamVjdD5CaW9waHlzaWNzPC9zdWJqZWN0PgogICAgPHN1YmplY3Q+QmlvY2hlbWlzdHJ5PC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc3ViamVjdFNjaGVtZT0iRk9SIj4yOTk5OSBQaHlzaWNhbCBTY2llbmNlcyBub3QgZWxzZXdoZXJlIGNsYXNzaWZpZWQ8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzdWJqZWN0U2NoZW1lPSJGaWVsZHMgb2YgU2NpZW5jZSBhbmQgVGVjaG5vbG9neSAoRk9TKSIgc2NoZW1lVVJJPSJodHRwOi8vd3d3Lm9lY2Qub3JnL3NjaWVuY2UvaW5uby8zODIzNTE0Ny5wZGYiPkZPUzogUGh5c2ljYWwgc2NpZW5jZXM8L3N1YmplY3Q+CiAgICA8c3ViamVjdCBzdWJqZWN0U2NoZW1lPSJGaWVsZHMgb2YgU2NpZW5jZSBhbmQgVGVjaG5vbG9neSAoRk9TKSI+Rk9TOiBQaHlzaWNhbCBzY2llbmNlczwvc3ViamVjdD4KICAgIDxzdWJqZWN0IHN1YmplY3RTY2hlbWU9IkZPUiI+Mzk5OTkgQ2hlbWljYWwgU2NpZW5jZXMgbm90IGVsc2V3aGVyZSBjbGFzc2lmaWVkPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc3ViamVjdFNjaGVtZT0iRmllbGRzIG9mIFNjaWVuY2UgYW5kIFRlY2hub2xvZ3kgKEZPUykiIHNjaGVtZVVSST0iaHR0cDovL3d3dy5vZWNkLm9yZy9zY2llbmNlL2lubm8vMzgyMzUxNDcucGRmIj5GT1M6IENoZW1pY2FsIHNjaWVuY2VzPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc3ViamVjdFNjaGVtZT0iRmllbGRzIG9mIFNjaWVuY2UgYW5kIFRlY2hub2xvZ3kgKEZPUykiPkZPUzogQ2hlbWljYWwgc2NpZW5jZXM8L3N1YmplY3Q+CiAgICA8c3ViamVjdD5JbW11bm9sb2d5PC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc3ViamVjdFNjaGVtZT0iRmllbGRzIG9mIFNjaWVuY2UgYW5kIFRlY2hub2xvZ3kgKEZPUykiIHNjaGVtZVVSST0iaHR0cDovL3d3dy5vZWNkLm9yZy9zY2llbmNlL2lubm8vMzgyMzUxNDcucGRmIj5GT1M6IENsaW5pY2FsIG1lZGljaW5lPC9zdWJqZWN0PgogICAgPHN1YmplY3Qgc3ViamVjdFNjaGVtZT0iRmllbGRzIG9mIFNjaWVuY2UgYW5kIFRlY2hub2xvZ3kgKEZPUykiPkZPUzogQ2xpbmljYWwgbWVkaWNpbmU8L3N1YmplY3Q+CiAgPC9zdWJqZWN0cz4KICA8ZGF0ZXM+CiAgICA8ZGF0ZSBkYXRlVHlwZT0iQ3JlYXRlZCI+MjAxNi0wNS0wNjwvZGF0ZT4KICAgIDxkYXRlIGRhdGVUeXBlPSJVcGRhdGVkIj4yMDE2LTA1LTA2PC9kYXRlPgogICAgPGRhdGUgZGF0ZVR5cGU9Iklzc3VlZCI+MjAxNjwvZGF0ZT4KICA8L2RhdGVzPgogIDxzaXplcy8+CiAgPGZvcm1hdHMvPgogIDx2ZXJzaW9uLz4KICA8cmlnaHRzTGlzdD4KICAgIDxyaWdodHMgcmlnaHRzVVJJPSJodHRwOi8vY3JlYXRpdmVjb21tb25zLm9yZy9saWNlbnNlcy9ieS8zLjAvdXMiPkNDLUJZPC9yaWdodHM+CiAgPC9yaWdodHNMaXN0PgogIDxkZXNjcmlwdGlvbnM+CiAgICA8ZGVzY3JpcHRpb24gZGVzY3JpcHRpb25UeXBlPSJBYnN0cmFjdCI+QSBmYWNpbGUgcHJvY2VkdXJlIGlzIGRldmVsb3BlZCBmb3Igb25lLXBvdCBzeW50aGVzaXMgb2YgYSBuZXcgZ3JvdXAgb2YgZGljeWFub2FuaWxpbmVzLiBUZXRyYWh5ZHJvLTRILXRoaW9weXJhbi00LW9uZSwgJmx0O2ImZ3Q7MSZsdDsvYiZndDssIHVuZGVyZ29lcyBhIHBzZXVkbyBmb3VyLWNvbXBvbmVudCByZWFjdGlvbiB3aXRoIHZhcmlvdXMgYWxkZWh5ZGVzIGJlYXJpbmcgZGlmZmVyZW50IGdyb3VwcyBhbmQgdHdvIGVxdWl2YWxlbnRzIG9mIG1hbG9ub25pdHJpbGUgaW4gYXF1ZW91cyBtZWRpYSBpbiB0aGUgcHJlc2VuY2Ugb2YgdHJpZXRoeWxhbWluZSAoRXQmbHQ7c3ViJmd0OzMmbHQ7L3N1YiZndDtOKS4gQXMgYSByZXN1bHQsIG5vdmVsIHRoaW9weXJhbi1mdXNlZCBkaWN5YW5vYW5pbGluZXMgJmx0O2ImZ3Q7NCZsdDsvYiZndDsgYXJlIGZvcm1lZCBlZmZpY2llbnRseSBpbiB0aGUgcmVhY3Rpb24gbWl4dHVyZXMgaW4gOTDigJM5NyUgeWllbGQgd2l0aGluIDnigJMxMuKAiWggbWl4aW5nIGF0IDQwwrBDLiBEdWUgdG8gdGhlIHBvbGFyaXR5IG9mIHRoZSBtZWRpdW0sIHByb2R1Y3RzIHByZWNpcGl0YXRlIGluIHRoZSBtaXh0dXJlIHNwb250YW5lb3VzbHkgYWxsb3dpbmcgZm9yIGVhc3kgcHVyaWZpY2F0aW9uIGJ5IHJlY3J5c3RhbGxpemF0aW9uIGF2b2lkaW5nIGN1bWJlcnNvbWUgY2hyb21hdG9ncmFwaGljIHNlcGFyYXRpb25zLiBDaGFyYWN0ZXJpemF0aW9uIG9mIHRoZSBwcm9kdWN0cyB3YXMgcGVyZm9ybWVkIGJ5IHNwZWN0cm9zY29waWMgbWV0aG9kcyBhbmQsIGluIG9uZSBjYXNlLCB3YXMgZnVydGhlciBzdXBwb3J0ZWQgYnkgWC1yYXkgY3J5c3RhbGxvZ3JhcGhpYyBleHBlcmltZW50cy48L2Rlc2NyaXB0aW9uPgogIDwvZGVzY3JpcHRpb25zPgo8L3Jlc291cmNlPgo=","url":"https://figshare.com/collectio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