{"data":{"id":"10.6084/m9.figshare.c.3169213","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.3169213","prefix":"10.6084","suffix":"m9.figshare.c.3169213","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Sharma, Pramod K.","nameType":"Personal","givenName":"Pramod K.","familyName":"Sharma","affiliation":[],"nameIdentifiers":[]},{"name":"Sakshi Balwani","affiliation":[],"nameIdentifiers":[]},{"name":"Mathur, Divya","nameType":"Personal","givenName":"Divya","familyName":"Mathur","affiliation":[],"nameIdentifiers":[]},{"name":"Shashwat Malhotra","affiliation":[],"nameIdentifiers":[]},{"name":"Brajendra K. Singh","affiliation":[],"nameIdentifiers":[]},{"name":"Prasad, Ashok K.","nameType":"Personal","givenName":"Ashok K.","familyName":"Prasad","affiliation":[],"nameIdentifiers":[]},{"name":"Len, Christophe","nameType":"Personal","givenName":"Christophe","familyName":"Len","affiliation":[],"nameIdentifiers":[]},{"name":"Eycken, Erik V. Van Der","nameType":"Personal","givenName":"Erik V. Van Der","familyName":"Eycken","affiliation":[],"nameIdentifiers":[]},{"name":"Balaram Ghosh","affiliation":[],"nameIdentifiers":[]},{"name":"Richards, Nigel G. J.","nameType":"Personal","givenName":"Nigel G. J.","familyName":"Richards","affiliation":[],"nameIdentifiers":[]},{"name":"Virinder S. Parmar","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Synthesis and anti-inflammatory activity evaluation of novel triazolyl-isatin hybrids"}],"publisher":"Figshare","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Microbiology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Physiology"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Clinical medicine","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Developmental Biology"}],"contributors":[],"dates":[{"date":"2016-05-05","dateType":"Created"},{"date":"2016-05-05","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"New isatin-triazole based hybrids have been synthesized and evaluated for their inhibitory activity of TNF-α induced expression of Intercellular Adhesion Molecule-1 (ICAM-1) on the surface of human endothelial cells. Structure-activity relationship (SAR) studies revealed that the presence of the electron-attracting bromo substituent at position-5 of the isatin moiety played an important role in enhancing the anti-inflammatory potential of the synthesized compounds. Z-1-[3-(1\u003ci\u003eH\u003c/i\u003e-1,2,4-Triazol-1-yl)propyl]-5-bromo-3-[2-(4-methoxyphenyl)hydrazono]indolin-2-one (\u003cb\u003e19\u003c/b\u003e) with an IC\u003csub\u003e50\u003c/sub\u003e = 20 μM and 89% ICAM-1 inhibition with MTD at 200 μM was found to be the most potent of all the synthesized derivatives. Introduction of 1,2,4-triazole ring and electron-donating methoxy group on the phenylhydrazone moiety resulted in four-fold increase of the anti-inflammatory activity.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://figshare.com/collections/Synthesis_and_anti_inflammatory_activity_evaluation_of_novel_triazolyl_isatin_hybrids/3169213","contentUrl":null,"metadataVersion":1,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"api","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2016-05-05T07:41:35.000Z","registered":"2016-05-05T07:41:36.000Z","published":"2016","updated":"2024-12-15T06:07:55.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.3169213","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}