{"data":{"id":"10.6084/m9.figshare.c.2853586","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2853586","prefix":"10.6084","suffix":"m9.figshare.c.2853586","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Rasoul Vafazadeh","affiliation":[],"nameIdentifiers":[]},{"name":"Jafari, Fariba","nameType":"Personal","givenName":"Fariba","familyName":"Jafari","affiliation":[],"nameIdentifiers":[]},{"name":"Heidari, Mohammad Mehdi","nameType":"Personal","givenName":"Mohammad Mehdi","familyName":"Heidari","affiliation":[],"nameIdentifiers":[]},{"name":"Willis, Anthony C.","nameType":"Personal","givenName":"Anthony C.","familyName":"Willis","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Alkyl chain length effect on construction of copper(II) complexes with tridentate Schiff base ligand and DNA interaction"}],"publisher":"Figshare","container":{},"publicationYear":2016,"subjects":[{"subject":"Biophysics"},{"subject":"Biochemistry"},{"subject":"29999 Physical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Physical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Physical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"},{"subject":"Molecular Biology"},{"subject":"Pharmacology"},{"subject":"Biotechnology"},{"subject":"39999 Chemical Sciences not elsewhere classified","subjectScheme":"FOR"},{"subject":"FOS: Chemical sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Chemical sciences","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Plant Biology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"FOS: Biological sciences","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2016-03-08","dateType":"Created"},{"date":"2016-04-27","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"CC-BY","rightsUri":"http://creativecommons.org/licenses/by/3.0/us"}],"descriptions":[{"description":"Two tridentate Schiff base ligands were synthesized by condensation of equimolar amounts of benzoylacetone and 2-amino-1-ethanol or 3-amino-1-propanol, H\u003csub\u003e2\u003c/sub\u003eL\u003csup\u003e1\u003c/sup\u003e and H\u003csub\u003e2\u003c/sub\u003eL\u003csup\u003e2\u003c/sup\u003e, respectively. The reaction of the Schiff base ligands with Cu(CH\u003csub\u003e3\u003c/sub\u003eCOO)\u003csub\u003e2\u003c/sub\u003e in methanol leads to (CuL\u003csup\u003e1\u003c/sup\u003e)\u003csub\u003e4\u003c/sub\u003e, \u003cb\u003e1\u003c/b\u003e and (CuL\u003csup\u003e2\u003c/sup\u003e)\u003csub\u003e2\u003c/sub\u003e, \u003cb\u003e2\u003c/b\u003e. In the tetranuclear cubane species, the tridentate H\u003csub\u003e2\u003c/sub\u003eL has both a chelating and a bridging mode, after double deprotonation of the enolic OH groups. The copper(II) centers are five-coordinate with a NO\u003csub\u003e4\u003c/sub\u003e donor set from the ligands. The coordination geometry around each copper ion is essentially square pyramidal with one nitrogen and two oxygens from one ligand and two oxygens of adjacent ligands from the next unit of the cubane. In dinuclear \u003cb\u003e2\u003c/b\u003e, H\u003csub\u003e2\u003c/sub\u003eL\u003csup\u003e2\u003c/sup\u003e has chelating and bridging modes after double deprotonation of the enolic OH groups. The dianionic form of the Schiff base coordinates forming a six-membered chelate ring with Cu(II). Two such monomeric CuL\u003csup\u003e2\u003c/sup\u003e entities are eventually linked through the alkoxo bridges to produce dinuclear \u003cb\u003e2\u003c/b\u003e. The absorption spectra strongly suggest that \u003cb\u003e2\u003c/b\u003e interacts with CT-DNA. Both \u003cb\u003e1\u003c/b\u003e and \u003cb\u003e2\u003c/b\u003e appear to be more efficient than the parent compound in DNA cleavage.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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