{"data":{"id":"10.6084/m9.figshare.c.2174300","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2174300","prefix":"10.6084","suffix":"m9.figshare.c.2174300","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Wei, Fu-Zheng","givenName":"Fu-Zheng","familyName":"Wei","affiliation":[],"nameIdentifiers":[]},{"name":"Cao, Ziyang","givenName":"Ziyang","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Xi","givenName":"Xi","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Hui","givenName":"Hui","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Cai, Mu-Yan","givenName":"Mu-Yan","familyName":"Cai","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Tingting","givenName":"Tingting","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Hattori, Naoko","givenName":"Naoko","familyName":"Hattori","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Donglai","givenName":"Donglai","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Du, Yipeng","givenName":"Yipeng","familyName":"Du","affiliation":[],"nameIdentifiers":[]},{"name":"Song, Boyan","givenName":"Boyan","familyName":"Song","affiliation":[],"nameIdentifiers":[]},{"name":"Cao, Lin-Lin","givenName":"Lin-Lin","familyName":"Cao","affiliation":[],"nameIdentifiers":[]},{"name":"Shen, Changchun","givenName":"Changchun","familyName":"Shen","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Lina","givenName":"Lina","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Haiying","givenName":"Haiying","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Yang, Yang","givenName":"Yang","familyName":"Yang","affiliation":[],"nameIdentifiers":[]},{"name":"Xie, Dan","givenName":"Dan","familyName":"Xie","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Fan","givenName":"Fan","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Ushijima, Toshikazu","givenName":"Toshikazu","familyName":"Ushijima","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Ying","givenName":"Ying","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Zhu, Wei-Guo","givenName":"Wei-Guo","familyName":"Zhu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Epigenetic regulation of autophagy by the methyltransferase EZH2 through an MTOR-dependent pathway"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2016,"subjects":[{"subject":"Biochemistry"},{"subject":"Medicine"},{"subject":"Cell Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Molecular Biology"},{"subject":"Physiology"},{"subject":"Pharmacology"},{"subject":"Chemical Sciences not elsewhere classified"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Marine Biology"},{"subject":"Cancer"}],"contributors":[],"dates":[{"date":"2016-01-08","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2016","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Macroautophagy is an evolutionarily conserved cellular process involved in the clearance of proteins and organelles. Although the autophagy regulation machinery has been widely studied, the key epigenetic control of autophagy process still remains unknown. Here we report that the methyltransferase EZH2 (enhancer of zeste 2 polycomb repressive complex 2 subunit) epigenetically represses several negative regulators of the MTOR (mechanistic target of rapamycin [serine/threonine kinase]) pathway, such as \u003ci\u003eTSC2\u003c/i\u003e, \u003ci\u003eRHOA\u003c/i\u003e, \u003ci\u003eDEPTOR\u003c/i\u003e, \u003ci\u003eFKBP11\u003c/i\u003e, \u003ci\u003eRGS16\u003c/i\u003e and \u003ci\u003eGPI\u003c/i\u003e. EZH2 was recruited to these genes promoters via MTA2 (metastasis associated 1 family, member 2), a component of the nucleosome remodeling and histone deacetylase (NuRD) complex. MTA2 was identified as a new chromatin binding protein whose association with chromatin facilitated the subsequent recruitment of EZH2 to silenced targeted genes, especially \u003ci\u003eTSC2\u003c/i\u003e. Downregulation of TSC2 (tuberous sclerosis 2) by EZH2 elicited MTOR activation, which in turn modulated subsequent MTOR pathway-related events, including inhibition of autophagy. In human colorectal carcinoma (CRC) tissues, the expression of MTA2 and EZH2 correlated negatively with expression of TSC2, which reveals a novel link among epigenetic regulation, the MTOR pathway, autophagy induction, and tumorigenesis.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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