{"data":{"id":"10.6084/m9.figshare.c.2168963.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2168963.v1","prefix":"10.6084","suffix":"m9.figshare.c.2168963.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Liu, Wei","givenName":"Wei","familyName":"Liu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Dongjian","givenName":"Dongjian","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Feng, Yuanbo","givenName":"Yuanbo","familyName":"Feng","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Yue","givenName":"Yue","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Huang, Dejian","givenName":"Dejian","familyName":"Huang","affiliation":[],"nameIdentifiers":[]},{"name":"Jiang, Cuihua","givenName":"Cuihua","familyName":"Jiang","affiliation":[],"nameIdentifiers":[]},{"name":"Gao, Meng","givenName":"Meng","familyName":"Gao","affiliation":[],"nameIdentifiers":[]},{"name":"Peng, Fei","givenName":"Fei","familyName":"Peng","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Xiaoning","givenName":"Xiaoning","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Jiang, Xiao","givenName":"Xiao","familyName":"Jiang","affiliation":[],"nameIdentifiers":[]},{"name":"Ni, Yicheng","givenName":"Yicheng","familyName":"Ni","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Jian","givenName":"Jian","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Jing, Su","givenName":"Su","familyName":"Jing","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Biodistribution and anti-tumor efficacy of intratumorally injected necrosis-avid theranostic agent radioiodinated hypericin in rodent tumor models"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Chemistry"},{"subject":"Biotechnology"},{"subject":"Pharmacology"},{"subject":"Cell Biology"},{"subject":"Biochemistry"}],"contributors":[],"dates":[{"date":"2015-12-18","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2168963","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"Hypericin has an excellent necrosis-specific targeting capacity; thus, we explored small-molecular tumor necrosis therapy (SMTNT) for inhibiting tumor growth in rodent tumor models. H22 and S180 tumor-bearing Kunming (KM) mice were intratumorally injected with \u003csup\u003e131\u003c/sup\u003eI-monoiodohypericin (\u003csup\u003e131\u003c/sup\u003eI-MIH) to investigate the biodistribution of \u003csup\u003e131\u003c/sup\u003eI-MIH as a function of time. Single-photon emission computed tomography (SPECT), autoradiography, fluorescence microscopy and hematoxylin and eosin (H\u0026amp;E) staining were performed to determine the intra-tumoral distribution of \u003csup\u003e131\u003c/sup\u003eI-MIH. A therapeutic evaluation study was also performed in the tumor-bearing KM mice using saline and a positive drug as controls. Gamma counting, SPECT images, autoradiography and fluorescence microscopy and H\u0026amp;E staining results revealed intense retention of \u003csup\u003e131\u003c/sup\u003eI-MIH in the necrotic tumor over 168 h and good \u003ci\u003ein vivo\u003c/i\u003e stability of the agent. Therapy with a single dose of intra-tumoral administration of \u003csup\u003e131\u003c/sup\u003eI-MIH caused significant tumor growth delay. A histopathological analysis of the tumors and normal organs further validated the therapeutic efficacy and limited systemic toxicity of \u003csup\u003e131\u003c/sup\u003eI-MIH. The prolonged tumor retention and effective therapy indicated that \u003csup\u003e131\u003c/sup\u003eI-MIH may be a promising intratumorally injected SMTNT agent.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/Biodistribution_and_anti_tumor_efficacy_of_intratumorally_injected_necrosis_avid_theranostic_agent_radioiodinated_hypericin_in_rodent_tumor_models/2168963/1","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-18T13:25:23.000Z","registered":"2015-12-18T13:25:24.000Z","published":"2015","updated":"2024-03-21T09:34:48.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2168963.v1","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]},"versionOf":{"data":[]}}}}