{"data":{"id":"10.6084/m9.figshare.c.2168072.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2168072.v1","prefix":"10.6084","suffix":"m9.figshare.c.2168072.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Bager, Peter","givenName":"Peter","familyName":"Bager","affiliation":[],"nameIdentifiers":[]},{"name":"Wohlfahrt, Jan","givenName":"Jan","familyName":"Wohlfahrt","affiliation":[],"nameIdentifiers":[]},{"name":"Sørensen, Erik","givenName":"Erik","familyName":"Sørensen","affiliation":[],"nameIdentifiers":[]},{"name":"Ullum, Henrik","givenName":"Henrik","familyName":"Ullum","affiliation":[],"nameIdentifiers":[]},{"name":"Lotte Nystrup Husemoen, Lise","givenName":"Lise","familyName":"Lotte Nystrup Husemoen","affiliation":[],"nameIdentifiers":[]},{"name":"Linneberg, Allan","givenName":"Allan","familyName":"Linneberg","affiliation":[],"nameIdentifiers":[]},{"name":"Melbye, Mads","givenName":"Mads","familyName":"Melbye","affiliation":[],"nameIdentifiers":[]},{"name":"P. Thyssen, Jacob","givenName":"Jacob","familyName":"P. Thyssen","affiliation":[],"nameIdentifiers":[]},{"name":"Kim Høgdall, Claus","givenName":"Claus","familyName":"Kim Høgdall","affiliation":[],"nameIdentifiers":[]},{"name":"Palle, Connie","givenName":"Connie","familyName":"Palle","affiliation":[],"nameIdentifiers":[]},{"name":"K. Kjær, Susanne","givenName":"Susanne","familyName":"K. Kjær","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Common filaggrin gene mutations and risk of cervical cancer"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Cancer"},{"subject":"Mathematics"},{"subject":"FOS: Mathematics","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Biological Sciences"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biotechnology"},{"subject":"Molecular Biology"},{"subject":"Genetics"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Cell Biology"}],"contributors":[],"dates":[{"date":"2015-12-17","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2168072","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003eBackground.\u003c/b\u003e As carriers of filaggrin gene (\u003ci\u003eFLG\u003c/i\u003e) mutations may have a compromised cervical mucosal barrier against human papillomavirus infection, our primary objective was to study their risk of cervical cancer.\u003cb\u003eMethods.\u003c/b\u003e We genotyped 586 cervical cancer patients for the two most common \u003ci\u003eFLG\u003c/i\u003e mutations, R501X and 2282del4, using blood from the Copenhagen Hospital Biobank, Denmark. Controls (n = 8050) were genotyped in previous population-based studies. Information on cervical cancer, mortality and emigration were obtained from national registers. Odds ratios (OR) were estimated by logistic regression with adjustment for age at blood sampling, and weighted by the genotype-specific inverse probability of death between diagnosis and sampling. Hazard ratios (HR) were estimated by Cox regression with time since diagnosis as underlying time, and with adjustment for age at diagnosis and stratification by cancer stage.\u003cb\u003eResults.\u003c/b\u003e The primary results showed that \u003ci\u003eFLG\u003c/i\u003e mutations were not associated with the risk of cervical cancer (6.3% of cases and 7.7% of controls were carriers; OR adjusted 0.81, 95% CI 0.57–1.14; OR adjusted+ weighted 0.96, 95% CI 0.58–1.57). Among cases, \u003ci\u003eFLG\u003c/i\u003e mutations increased mortality due to cervical cancer (HR 4.55, 95% CI 1.70–12.2), however, the association was reduced after stratification by cancer stage (HR 2.53, 95% CI 0.84–7.59).\u003cb\u003eConclusion.\u003c/b\u003e Carriage of \u003ci\u003eFLG\u003c/i\u003e mutations was not associated with the risk of cervical cancer.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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