{"data":{"id":"10.6084/m9.figshare.c.2127992","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2127992","prefix":"10.6084","suffix":"m9.figshare.c.2127992","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Yu, Yan","givenName":"Yan","familyName":"Yu","affiliation":[],"nameIdentifiers":[]},{"name":"Zhao, Miao","givenName":"Miao","familyName":"Zhao","affiliation":[],"nameIdentifiers":[]},{"name":"Yu, Lili","givenName":"Lili","familyName":"Yu","affiliation":[],"nameIdentifiers":[]},{"name":"Pan, Xiaohong","givenName":"Xiaohong","familyName":"Pan","affiliation":[],"nameIdentifiers":[]},{"name":"Wu, Lingling","givenName":"Lingling","familyName":"Wu","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Immunotoxic effect of arsenic trioxide on \u003ci\u003eCaenorhabditis elegans\u003c/i\u003e"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Science Policy"},{"subject":"Developmental Biology"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Ecology"},{"subject":"FOS: Biological sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Earth and Environmental Sciences"},{"subject":"Biochemistry"},{"subject":"Biophysics"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"A \u003ci\u003ePseudomonas aeruginosa\u003c/i\u003e–\u003ci\u003eCaenorhabditis elegans\u003c/i\u003e pathogenesis model was utilized to assess immunotoxic effects of arsenic trioxide (As\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e). After 2 h of As\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e exposure, 500 µmol L\u003csup\u003e−1\u003c/sup\u003e and 1 mmol L\u003csup\u003e−1\u003c/sup\u003e As\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e treatment significantly decreased median survivals of \u003ci\u003eC. elegans\u003c/i\u003e (10 h after L4/adult molt). However, 2 h of As\u003csub\u003e2\u003c/sub\u003eO\u003csub\u003e3\u003c/sub\u003e exposure caused no significant changes in the survivals rates of \u003ci\u003eC. elegans\u003c/i\u003e (2 h after L4/adult molt). Notably, a significant dose-related immunoenhancement was observed in \u003ci\u003eC. elegans\u003c/i\u003e (2 h after L4/adult molt) after 12 h of arsenite exposure.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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","url":"https://tandf.figshare.com/collections/Immunotoxic_effect_of_arsenic_trioxide_on_i_Caenorhabditis_elegans_i_/2127992","contentUrl":null,"metadataVersion":2,"schemaVersion":"http://datacite.org/schema/kernel-4","source":"mds","isActive":true,"state":"findable","reason":null,"viewCount":0,"viewsOverTime":[],"downloadCount":0,"downloadsOverTime":[],"referenceCount":0,"citationCount":0,"citationsOverTime":[],"partCount":0,"partOfCount":0,"versionCount":0,"versionOfCount":0,"created":"2015-12-05T18:59:32.000Z","registered":"2015-12-05T18:59:33.000Z","published":"2015","updated":"2024-03-21T09:32:45.000Z"},"relationships":{"client":{"data":{"id":"figshare.ars","type":"clients"}},"provider":{"data":{"id":"otjm","type":"providers"}},"media":{"data":{"id":"10.6084/m9.figshare.c.2127992","type":"media"}},"references":{"data":[]},"citations":{"data":[]},"parts":{"data":[]},"partOf":{"data":[]},"versions":{"data":[]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