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Fuel emissions were diluted to target fine particulate matter (PM\u003csub\u003e2.5\u003c/sub\u003e) concentrations of 50, 150, or 500 μg/m\u003csup\u003e3\u003c/sup\u003e. Studies in healthy mice showed greater levels of neutrophils and MIP-2 in bronchoalveolar lavage (BAL) fluid 2 h after a single 4-h exposure to B0 compared with mice exposed to B20 or B100. No consistent differences in BAL cells and biochemistry, or hematological parameters, were observed after 5 d or 4 weeks of exposure to any of the emissions. Air-exposed HDM-allergic mice had significantly increased responsiveness to methacholine aerosol challenge compared with non-allergic mice. Exposure to any of the emissions for 4 weeks did not further increase responsiveness in either non-allergic or HDM-allergic mice, and few parameters of allergic inflammation in BAL fluid were altered. Lung and nasal pathology were not significantly different among B0-, B20-, or B100-exposed groups. 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    <title>Soy biodiesel emissions have reduced inflammatory effects compared to diesel emissions in healthy and allergic mice</title>
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