{"data":{"id":"10.6084/m9.figshare.c.2121878.v1","type":"dois","attributes":{"doi":"10.6084/m9.figshare.c.2121878.v1","prefix":"10.6084","suffix":"m9.figshare.c.2121878.v1","identifiers":[],"alternateIdentifiers":[],"creators":[{"name":"Li, Jing-Xin","givenName":"Jing-Xin","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Wang, Ling","givenName":"Ling","familyName":"Wang","affiliation":[],"nameIdentifiers":[]},{"name":"Zhang, Xue-Feng","givenName":"Xue-Feng","familyName":"Zhang","affiliation":[],"nameIdentifiers":[]},{"name":"Li, Jing","givenName":"Jing","familyName":"Li","affiliation":[],"nameIdentifiers":[]},{"name":"Zhu, Feng-Cai","givenName":"Feng-Cai","familyName":"Zhu","affiliation":[],"nameIdentifiers":[]},{"name":"Song, Yu-Fei","givenName":"Yu-Fei","familyName":"Song","affiliation":[],"nameIdentifiers":[]},{"name":"Hu, Yuan-Sheng","givenName":"Yuan-Sheng","familyName":"Hu","affiliation":[],"nameIdentifiers":[]},{"name":"Hu, Yue-Mei","givenName":"Yue-Mei","familyName":"Hu","affiliation":[],"nameIdentifiers":[]},{"name":"Xia, Jie-Lai","givenName":"Jie-Lai","familyName":"Xia","affiliation":[],"nameIdentifiers":[]}],"titles":[{"title":"Two-year efficacy and immunogenicity of Sinovac Enterovirus 71 vaccine against hand, foot and mouth disease in children"}],"publisher":"Taylor \u0026 Francis","container":{},"publicationYear":2015,"subjects":[{"subject":"Virology"},{"subject":"Infectious Diseases"},{"subject":"FOS: Health sciences","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Science Policy"},{"subject":"Biological Sciences"},{"subject":"Immunology"},{"subject":"FOS: Clinical medicine","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"},{"subject":"Sociology"},{"subject":"FOS: Sociology","schemeUri":"http://www.oecd.org/science/inno/38235147.pdf","subjectScheme":"Fields of Science and Technology (FOS)"}],"contributors":[],"dates":[{"date":"2015-12-05","dateType":"Created"},{"date":"2019-08-19","dateType":"Updated"},{"date":"2015","dateType":"Issued"}],"language":null,"types":{"ris":"GEN","bibtex":"misc","citeproc":"article","schemaOrg":"Collection","resourceType":"Collection","resourceTypeGeneral":"Collection"},"relatedIdentifiers":[{"relationType":"IsIdenticalTo","relatedIdentifier":"10.6084/m9.figshare.c.2121878","relatedIdentifierType":"DOI"}],"relatedItems":[],"sizes":[],"formats":[],"version":null,"rightsList":[{"rights":"Creative Commons Attribution 4.0 International","rightsUri":"https://creativecommons.org/licenses/by/4.0/legalcode","schemeUri":"https://spdx.org/licenses/","rightsIdentifier":"cc-by-4.0","rightsIdentifierScheme":"SPDX"}],"descriptions":[{"description":"\u003cb\u003eObjectives\u003c/b\u003e: To evaluate the efficacy and immunogenicity of the Sinovac Enterovirus 71 (EV71) vaccine for up to two years. \u003cb\u003eMethods\u003c/b\u003e: We did a follow-up study of our initial randomized trial in 10,077 participants, who were randomized to receive EV71 vaccine or placebo in a 1:1 ratio and followed for 14 months. The extended follow-up study lasted for another 12 months and EV71-associated hand, foot, and mouth disease (HFMD) was the primary endpoint. \u003cb\u003eResults\u003c/b\u003e: The EV71 vaccine showed an efficacy of 95.1% (95%CI 63.6, 99.3) against EV71-associated HFMD during the extended follow-up and an overall efficacy of 94.7% (95%CI 87.8, 97.6) for two years. The EV71 vaccine elicited a sustained high level of neutralizing antibodies in participants, and no serious adverse event was judged to be related to the vaccination. \u003cb\u003eConclusion\u003c/b\u003e: The Sinovac EV71 vaccine could provide a sustained high protection against EV71-associated HFMDs for up to 2 years.","descriptionType":"Abstract"}],"geoLocations":[],"fundingReferences":[],"xml":"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